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Acute Myeloid Leukemia (non-APL)

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IDDIS-AML
TipoDoença
Alegais
AMLANLLLeucemia mieloide agudaAcute non-lymphocytic leukemiaГострий мієлобластний лейкозГострий мієлоїдний лейкоз (не-APL)
Estadoreviewed 2026-04-25 | pending_clinical_signoff
DoençasNenhuma declaração
FontesSRC-ELN-AML-2022 SRC-ESMO-AML-2020 SRC-NCCN-AML-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Fonte YAML

icd_o_3_morphology9861/3
icd_o_3_topography["C42.1"]
icd_10C92.0
who_classificationAcute myeloid leukemia (per WHO 5th ed. / ICC 2022) — non-APL subtypes

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Risk-stratified archetype. The fundamental treatment split is fit-vs-unfit for intensive 7+3 induction (age, comorbidity, ECOG). Within fit patients, FLT3-ITD/TKD adds midostaurin (RATIFY); within unfit, ven+aza (VIALE-A) is now the 1L standard. APL (PML-RARA) is a separate disease with completely different therapy (ATRA + ATO) — see DIS-APL. STUB — requires clinical co-lead signoff before publication. Myeloid expansion (heme) — first myeloid disease end-to-end.

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