AML with FLT3-ITD or FLT3-TKD mutation — addition of midostaurin (or gilteritinib in r/r)...

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ID	`RF-AML-FLT3-ACTIONABLE`
Tipo	Sinal de alerta
Estado	reviewed 2026-04-25 \| pending_clinical_signoff
Doenças	`DIS-AML`
Fontes	`SRC-ELN-AML-2022` `SRC-NCCN-AML-2025` `SRC-RATIFY-STONE-2017`

Origem da bandeira vermelha

Definição	AML with FLT3-ITD or FLT3-TKD mutation — addition of midostaurin (or gilteritinib in r/r) to induction is required (RATIFY trial)
Direcção clínica	intensificar
Categoria	high-risk-biology
Algoritmo de deslocamentos	ALGO-AML-1L

Lógica de Desencadeamento

{
  "any_of": [
    {
      "finding": "flt3_itd",
      "value": true
    },
    {
      "finding": "flt3_tkd",
      "value": true
    },
    {
      "finding": "flt3_mutation",
      "value": "positive"
    }
  ],
  "type": "biomarker"
}

Notas

Triggers addition of midostaurin 50 mg PO BID days 8-21 to 7+3 induction + HiDAC consolidation in fit patients. Gilteritinib is the r/r-AML standard. NOT applicable for unfit patients on ven+aza (FLT3-targeting in that setting under investigation; not yet standard). Access: midostaurin not Ukraine-reimbursed — major barrier. STUB — requires clinical co-lead signoff.

Usado por

Algoritmos

ALGO-AML-1L - ALGO-AML-1L
ALGO-AML-2L - ALGO-AML-2L

Indicação

IND-AML-1L-QUIZARTINIB-FLT3ITD - IND-AML-1L-QUIZARTINIB-FLT3ITD
IND-AML-2L-GILTERITINIB-FLT3 - IND-AML-2L-GILTERITINIB-FLT3

Sinal de alerta

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