Onco Wiki / Disease

Colorectal carcinoma (CRC)

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDDIS-CRC
TypeDisease
Aliases
Bowel cancerColon cancer + Rectal cancerColorectal carcinomaКолоректальний рак
Statusreviewed 2026-04-26 | pending_clinical_signoff
DiseasesNone declared
SourcesSRC-ESMO-COLON-2024 SRC-NCCN-COLON-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Source YAML

icd_o_3_morphology8140/3
icd_o_3_topography["C18", "C19", "C20"]
icd_10C18-C20
who_classificationWHO Digestive System Tumours 5th ed (2019): Adenocarcinoma of the colon and rectum

Capabilities

Notes

Combined colon + rectum scope. The two share most systemic-therapy decisions (FOLFOX/CAPOX adjuvant, FOLFIRINOX/FOLFOX+bev/cetux/panit metastatic, pembro MSI-H 1L) but rectum has additional neoadjuvant CRT / TNT decisions that the current schema cannot cleanly express (see PROPOSAL §17). For now, rectum-specific neoadjuvant logic is documented in Indication.notes free-text; full sequencing awaits proposal ratification. Required biomarkers per NCCN colon v4.2025 §pretreatment for any stage III–IV: MSI / dMMR (treatment-defining for MSI-H), RAS extended (KRAS exons 2-4 + NRAS exons 2-4), BRAF V600E, HER2 (rare but actionable in RAS-WT).

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