Patient has a confirmed germline APC pathogenic variant. Mandates structured colorectal +...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-FAP-CONFIRMED-CARRIER`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-CRC` `DIS-GASTRIC` `DIS-PDAC`
Sources	`SRC-ASCO-ACMG-LYNCH-2014` `SRC-ESMO-CRC-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Patient has a confirmed germline APC pathogenic variant. Mandates structured colorectal + upper-GI surveillance + prophylactic colectomy timing decision. Confirmed-carrier RedFlag (§20 v0.2-B).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "germline_apc_pathogenic_variant_confirmed",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona confirmed-carrier RedFlag for FAP. Severity=critical because untreated classic FAP has ~100% lifetime CRC risk by age 40 — prophylactic colectomy is curative and time-sensitive.

Used By

Algorithms

ALGO-PREVENTION-RISK-TRIAGE-OVERVIEW - ALGO-PREVENTION-RISK-TRIAGE-OVERVIEW

Indications

IND-FAP-CARRIER-INTENSIFIED - IND-FAP-CARRIER-INTENSIFIED
IND-FAP-CARRIER-SURVEILLANCE - IND-FAP-CARRIER-SURVEILLANCE

Red flag

RF-FAP-FAMILY-HISTORY-SUSPICION - Family pedigree suggestive of Familial Adenomatous Polyposis (FAP) or the attenuated FAP...