Obesity — BMI ≥30 kg/m² (per WHO definition) — OR class 2/3 obesity with BMI ≥35 / ≥40. I...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-LIFESTYLE-OBESITY-CANCER-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-BREAST` `DIS-CRC` `DIS-ENDOMETRIAL` `DIS-ESOPHAGEAL` `DIS-HCC` `DIS-RCC`
Sources	`SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Obesity — BMI ≥30 kg/m² (per WHO definition) — OR class 2/3 obesity with BMI ≥35 / ≥40. IARC + WCRF/AICR establish obesity as an etiological factor for ≥13 cancers: post-menopausal breast cancer, endometrial, colorectal, esophageal adenocarcinoma, gastric cardia, hepatocellular carcinoma (via NAFLD/MASH), renal cell carcinoma, ovarian, pancreatic, gallbladder, multiple myeloma, meningioma, and thyroid. Population-attributable fraction varies by cancer (~30-40% for endometrial; ~5-10% for many others). Sustained weight reduction (especially ≥10% BMI) produces meaningful cancer-incidence reduction particularly for hormonally-driven tumors. Prevention-persona RedFlag.
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "bmi_ge_30",
      "value": true
    },
    {
      "finding": "bmi_ge_35",
      "value": true
    },
    {
      "finding": "bmi_ge_40",
      "value": true
    },
    {
      "finding": "obesity_class_diagnosis",
      "value": "positive"
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for obesity (BMI ≥30). Engine routes to PreventionPlan recommending structured weight-loss intervention + bariatric surgery discussion in class 2/3 obesity + cancer screening per BMI-elevated risk profile. STUB pending two-Clinical-Co-Lead signoff.

Used By

Indications

IND-LIFESTYLE-OBESITY-PREVENTION-OBSERVATION - IND-LIFESTYLE-OBESITY-PREVENTION-OBSERVATION
IND-LIFESTYLE-OBESITY-PREVENTION-WEIGHT-LOSS - IND-LIFESTYLE-OBESITY-PREVENTION-WEIGHT-LOSS