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Low adherence to a Mediterranean dietary pattern (Trichopoulou Mediterranean Diet Score [...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-LIFESTYLE-LOW-MEDITERRANEAN-DIET-PREVENTION
TypeRed flag
Statusreviewed 2026-05-18 | pending_clinical_signoff
DiseasesDIS-CRC
SourcesSRC-NCCN-BCELL-2025 SRC-NCCN-COLON-2025

Red Flag Origin

DefinitionLow adherence to a Mediterranean dietary pattern (Trichopoulou Mediterranean Diet Score [MDS] 0-3 of 9, or PREDIMED-style score in the lowest tertile, or 14-item MEDAS <7). Mediterranean dietary pattern = high intake of olive oil, vegetables, fruits, whole grains, legumes, nuts, fish; moderate dairy + wine with meals; low intake of red/processed meat + sweets. EPIC + Nurses' Health Study + PREDIMED cohorts: high adherence associated with ~12-15% reduction in overall cancer incidence + mortality; strongest signals for CRC, breast, gastric, hepatocellular cancers + dietary-pattern co-benefits for cardiovascular disease (PREDIMED 2013 RCT primary endpoint). Mechanisms: high polyphenol (olive oil, vegetables) + ω-3 fatty acid (fish) + fibre + antioxidant content; low pro-inflammatory red/ processed meat + refined-carbohydrate content; favorable microbiome modulation. Prevention-persona RedF...
Clinical directioninvestigate
Categoryother

Trigger Logic

{
  "any_of": [
    {
      "finding": "mediterranean_diet_score_lt_4",
      "value": true
    },
    {
      "finding": "medas_score_lt_7",
      "value": true
    },
    {
      "finding": "predimed_lowest_tertile",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for low Mediterranean-diet adherence. Population-level dietary-pattern lever — distinct from single-nutrient RFs (fibre, calcium, red meat). PREDIMED RCT (2013 primary endpoint cardiovascular; 2015 secondary CRC analysis) + EPIC + NHS observational signal. Anchored to DIS-CRC because pattern-cancer evidence is strongest there; multi-cancer benefit framed in rationale. Engine routes to PreventionPlan recommending dietary-pattern counseling + USPSTF-cadence screening per anchor. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Used By

Indications