Colorectal carcinoma (CRC) · Trifluridine-Tipiracil + Bevacizumab (SUNLIGHT) — 3L+ mCRC
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
Knowledge-base record for audit. Provisional clinical content: this is not a prescription. An oncologist must verify original sources, applicability and review status. Full rules and constraints are in the YAML.
| Track | standard |
|---|---|
| Linked regimen | REG-TRIFLURIDINE-TIPIRACIL-BEV |
| ID | IND-CRC-METASTATIC-3L-TAS102-BEV |
|---|---|
| Type | Indication |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | DIS-CRC |
| Sources | SRC-ESMO-COLON-2024 SRC-NCCN-COLON-2025 |
Notes
STUB — pending Clinical Co-Lead sign-off. Standard-track 3L+ for chemo-refractory mCRC. MSI-H continues pembrolizumab past 3L (separate continuation track). BRAF V600E switches to encorafenib + cetuximab earlier (2L+, existing IND-CRC-METASTATIC-2L-BRAF-BEACON). Regorafenib (IND-CRC-METASTATIC-3L-REGORAFENIB) is the alternative 3L+ option when TAS-102+bev funding unavailable.
Used By
Algorithms
ALGO-CRC-METASTATIC-2L- ALGO-CRC-METASTATIC-2LALGO-CRC-METASTATIC-3L- ALGO-CRC-METASTATIC-3L
Indication
IND-CRC-3L-FRUQUINTINIB- IND-CRC-3L-FRUQUINTINIBIND-CRC-METASTATIC-3L-TRIFLURIDINE-TIPIRACIL-MONO- IND-CRC-METASTATIC-3L-TRIFLURIDINE-TIPIRACIL-MONO