NRAS codon 12 mutation in mCRC — extended RAS WT criterion fails; anti-EGFR contraindicat...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-NRAS-G12-CRC |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-CRC |
| Sources | SRC-CIVIC SRC-NCCN-COLON-2025 |
Actionability Facts
| Biomarker | BIO-RAS-MUTATION |
|---|---|
| Variant | NRAS G12 |
| Disease | DIS-CRC |
| ESCAT tier | IB |
| Contraindicated monotherapy | cetuximab / panitumumab |
| Evidence summary | NRAS codon 12 mutation in mCRC — extended RAS WT criterion fails; anti-EGFR contraindicated. |
Notes
ESCAT IB.
Used By
No reverse references found in the YAML corpus.