Low physical activity / sedentary lifestyle — defined as <150 min/week moderate-intensity...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-LIFESTYLE-SEDENTARY-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-BREAST` `DIS-CRC` `DIS-ENDOMETRIAL`
Sources	`SRC-NCCN-BCELL-2025` `SRC-NCCN-COLON-2025`

Red Flag Origin

Definition	Low physical activity / sedentary lifestyle — defined as <150 min/week moderate-intensity OR <75 min/week vigorous-intensity aerobic activity per WHO + US DHHS Physical Activity Guidelines, OR cumulative sedentary time ≥8h/day. Inverse association with multiple cancers — strongest evidence for colorectal cancer (~20-25% risk reduction with adequate activity per WCRF/AICR convincing-evidence rating), endometrial cancer (~20%), postmenopausal breast cancer (~10-15%). Probable additional protection for esophageal adenocarcinoma, kidney, bladder, gastric- cardia, lung. Mechanisms: insulin/IGF-1 axis, sex hormones, chronic inflammation, body fatness mediation. Prevention-persona RedFlag (§20 v0.3 lifestyle pilot).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "physical_activity_below_who_threshold",
      "value": true
    },
    {
      "finding": "moderate_activity_lt_150min_per_week",
      "value": true
    },
    {
      "finding": "sedentary_time_ge_8h_per_day",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for sedentary lifestyle / low physical activity. WCRF/AICR convincing-evidence rating for CRC + endometrial + postmenopausal breast cancer protection. Engine routes to PreventionPlan recommending structured physical-activity counseling per HHS + ACS guidelines. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Used By

Indications

IND-LIFESTYLE-SEDENTARY-PREVENTION-ACTIVITY - IND-LIFESTYLE-SEDENTARY-PREVENTION-ACTIVITY
IND-LIFESTYLE-SEDENTARY-PREVENTION-OBSERVATION - IND-LIFESTYLE-SEDENTARY-PREVENTION-OBSERVATION