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Habitual high red-meat consumption (≥500 g/week of cooked unprocessed red meat — beef, la...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-LIFESTYLE-HIGH-RED-MEAT-CRC-PREVENTION
TypeRed flag
Statusreviewed 2026-05-18 | pending_clinical_signoff
DiseasesDIS-CRC
SourcesSRC-NCCN-BCELL-2025 SRC-NCCN-COLON-2025

Red Flag Origin

DefinitionHabitual high red-meat consumption (≥500 g/week of cooked unprocessed red meat — beef, lamb, pork, veal) OR habitual processed-meat consumption (≥50 g/day — sausages, ham, bacon, salami, cured/smoked/ salted/preserved meat). IARC Monograph 114 (2015): processed meat Group 1 (sufficient evidence for CRC); red meat Group 2A (probable carcinogen). WCRF/AICR convincing-evidence rating for processed meat and CRC; probable for red meat. Each 50 g/day processed meat raises CRC risk ~18% (RR ~1.18); each 100 g/day red meat raises CRC risk ~17% (RR ~1.17). Mechanisms: N-nitroso compounds (NOCs) from nitrite preservatives + endogenous formation; heterocyclic amines (HCAs) + polycyclic aromatic hydrocarbons (PAHs) from high-temperature cooking; heme iron promoting reactive-oxygen species in colonocytes. Prevention- persona RedFlag (§20 v0.3 diet pilot, 2026-05-18). Distinct from RF-LIFESTYLE-PROCE...
Clinical directioninvestigate
Categoryother

Trigger Logic

{
  "any_of": [
    {
      "finding": "red_meat_intake_ge_500g_per_week",
      "value": true
    },
    {
      "finding": "processed_meat_intake_ge_50g_per_day",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag combining red-meat ≥500g/week + processed-meat ≥50g/day thresholds per WCRF/AICR + IARC Monograph 114. Severity:major because processed-meat exposure is Group-1 carcinogen with population-attributable fraction ~13% for CRC (WCRF/AICR). Engine routes to PreventionPlan recommending dietary substitution + CRC screening per USPSTF. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode. Coexists with existing RF-LIFESTYLE-PROCESSED-MEAT-PREVENTION — both may fire.

Used By

Indications