L'expression de protéines de réparation de la mismatch par IHC
Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.
| ID | BIO-DMMR-IHC |
|---|---|
| Type | Biomarqueur |
| Alias | Panneau MLH1/MSH2/MSH6/PMS2MMR IHCdMMR / pMMR par IHCЕкспресія MMR-білків (ІГХ) |
| État | examiné 2026-04-26 |
| Maladies | DIS-CRC DIS-ENDOMETRIAL DIS-GASTRIC DIS-OVARIAN DIS-PARATHYROID-CARCINOMA DIS-PROSTATE DIS-UROTHELIAL |
| Sources | SRC-NCCN-COLON-2025 |
Données biomarqueurs
| Type de biomarqueur | protein_expression_ihc |
|---|---|
| Mesure | MéthodeIHC pour MLH1, MSH2, MSH6, PMS2 sur FFPE; perte de toute → dMMR Unitéscategorical: dMMR (≥1 protein lost) | pMMR (all retained) Arrondissementcatégorique |
| Biomarqueurs connexes | BIO-MSI-STATUS |
Utilisé par
Pertinence thérapeutique
BMA-EPCAM-GERMLINE-CRC- La suppression germinale EPCAM (3' fin) silence le MSH2 en aval par hyperméthylation du promoteur →...BMA-EPCAM-GERMLINE-ENDOMETRIAL- La suppression germinale EPCAM silence MSH2 → syndrome de Lynch avec dMMR cancer endométrial phéno...BMA-MLH1-GERMLINE-CRC- MLH1 germline loss-of-function in crc produces dMMR/MSI-H phenotype. Pan-tumor MSI-H ICI...BMA-MLH1-GERMLINE-ENDOMETRIAL- MLH1 germline loss-of-function in endometrial produces dMMR/MSI-H phenotype. Pan-tumor MS...BMA-MLH1-GERMLINE-GASTRIC- MLH1 germline loss-of-function in gastric produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MLH1-GERMLINE-OVARIAN- MLH1 germline loss-of-function in ovarian produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MLH1-GERMLINE-PROSTATE- MLH1 germline loss-of-function in prostate produces dMMR/MSI-H phenotype. Pan- tumor MSI-...BMA-MLH1-GERMLINE-UROTHELIAL- MLH1 germline loss-of-function in urothelial produces dMMR/MSI-H phenotype. Pan-tumor MSI...BMA-MLH1-SOMATIC-CRC- MLH1 somatic loss-of-function in crc produces dMMR/MSI-H phenotype. Pan-tumor MSI-H ICI e...BMA-MLH1-SOMATIC-ENDOMETRIAL- MLH1 somatic loss-of-function in endometrial produces dMMR/MSI-H phenotype. Pan-tumor MSI...BMA-MLH1-SOMATIC-GASTRIC- MLH1 somatic loss-of-function in gastric produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MLH1-SOMATIC-OVARIAN- MLH1 somatic loss-of-function in ovarian produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MLH1-SOMATIC-PROSTATE- MLH1 somatic loss-of-function in prostate produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MLH1-SOMATIC-UROTHELIAL- MLH1 somatic loss-of-function in urothelial produces dMMR/MSI-H phenotype. Pan-tumor MSI-...BMA-MSH2-GERMLINE-CRC- MSH2 germline loss-of-function in crc produces dMMR/MSI-H phenotype. Pan-tumor MSI-H ICI...BMA-MSH2-GERMLINE-ENDOMETRIAL- MSH2 germline loss-of-function in endometrial produces dMMR/MSI-H phenotype. Pan-tumor MS...BMA-MSH2-GERMLINE-GASTRIC- MSH2 germline loss-of-function in gastric produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH2-GERMLINE-OVARIAN- MSH2 germline loss-of-function in ovarian produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH2-GERMLINE-PROSTATE- MSH2 germline loss-of-function in prostate produces dMMR/MSI-H phenotype. Pan- tumor MSI-...BMA-MSH2-GERMLINE-UROTHELIAL- MSH2 germline loss-of-function in urothelial produces dMMR/MSI-H phenotype. Pan-tumor MSI...BMA-MSH2-SOMATIC-CRC- Perte somatique de fonction MSH2 dans le crc produit dMMR/MSI-H phénotype. Pan-tumor MSI-H ICI e...BMA-MSH2-SOMATIC-ENDOMETRIAL- MSH2 somatic loss-of-function in endometrial produces dMMR/MSI-H phenotype. Pan-tumor MSI...BMA-MSH2-SOMATIC-GASTRIC- MSH2 somatic loss-of-function in gastric produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH2-SOMATIC-OVARIAN- MSH2 somatic loss-of-function in ovarian produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH2-SOMATIC-PROSTATE- MSH2 somatic loss-of-function in prostate produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH2-SOMATIC-UROTHELIAL- MSH2 somatic loss-of-function in urothelial produces dMMR/MSI-H phenotype. Pan-tumor MSI-...BMA-MSH6-GERMLINE-CRC- MSH6 germline loss-of-function in crc produces dMMR/MSI-H phenotype. Pan-tumor MSI-H ICI...BMA-MSH6-GERMLINE-ENDOMETRIAL- La perte de fonction germinale MSH6 dans l'endomètre produit le phénotype dMMR/MSI-H.BMA-MSH6-GERMLINE-GASTRIC- MSH6 germline loss-of-function in gastric produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH6-GERMLINE-OVARIAN- MSH6 germline loss-of-function in ovarian produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH6-GERMLINE-PROSTATE- MSH6 germline loss-of-function in prostate produces dMMR/MSI-H phenotype. Pan- tumor MSI-...BMA-MSH6-GERMLINE-UROTHELIAL- MSH6 germline loss-of-function in urothelial produces dMMR/MSI-H phenotype. Pan-tumor MSI...BMA-MSH6-SOMATIC-CRC- La perte de fonction somatique MSH6 dans le crc produit le phénotype dMMR/MSI-H. Pan-tumor MSI-H ICI e...BMA-MSH6-SOMATIC-ENDOMETRIAL- MSH6 somatic loss-of-function in endometrial produces dMMR/MSI-H phenotype. Pan-tumor MSI...BMA-MSH6-SOMATIC-GASTRIC- MSH6 somatic loss-of-function in gastric produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH6-SOMATIC-OVARIAN- MSH6 somatic loss-of-function in ovarian produces dMMR/MSI-H phenotype. Pan- tumor MSI-H...BMA-MSH6-SOMATIC-PROSTATE- MSH6 perte somatique de fonction dans la prostate produit dMMR/MSI-H phénotype. Pan- tumeur MSI-H...BMA-MSH6-SOMATIC-UROTHELIAL- MSH6 somatic loss-of-function in urothelial produces dMMR/MSI-H phenotype. Pan-tumor MSI-...BMA-MSI-STATUS-CRC- MSI-H (mistoratellite instability-high) CRC est le biomarqueur primaire pour les pembr...BMA-MSI-STATUS-ENDOMETRIAL- Le cancer de l'endomètre MSI-H/dMMR (~25-30% des cas avancés) est admissible à un régime fondé sur l'ICI...- ... 12 de plus
Biomarqueur
BIO-LYNCH-PANEL-SPLIT- Panneau germinatif du syndrome de Lynch — résolu par des gènes (MLH1 / MSH2 / MSH6 / PMS2 / EPCAM)BIO-MSI-STATUS- État d'instabilité des microsatellitesBIO-POLD1-HYPERMUTATOR- phénotype d'hypermutateur POLD1 ( mutation du domaine de la lecture d'épreuve)BIO-POLE-HYPERMUTATOR- phénotype d'hypermutateur POLE ( mutation du domaine de la lecture d'épreuve)BIO-TMB-HIGH- Tumor mutational burden (TMB-high)BIO-TP53-IHC- TP53 IHC (modèle d'expression aberrant p53)
Indication
IND-ENDOMETRIAL-2L-DOSTARLIMAB-DMMR- IND-ENDOMETRIAL-2L-DOSTARLIMAB-DMMRIND-ENDOMETRIAL-2L-PEMBRO-LENVA-PMMR- IND-ENDOMETRIAL-2L-PEMBRO-LENVA-PMMRIND-ENDOMETRIAL-ADVANCED-1L-DOSTARLIMAB-CHEMO- IND-ENDOMETRIAL-ADVANCED-1L-DOSTARLIMAB-CHEMO
Questionnaires
QUEST-ENDOMETRIAL-1L-STUB- Carcinome endométrial — première ligne
Signal d’alerte
RF-ENDOMETRIAL-HIGH-RISK-BIOLOGY- dMMR/MSI-high OR p53-abnormal OR POLE-mutated — TCGA classification drives ICI eligibilit...RF-PARATHYROID-CARCINOMA-MSI-TMB-HIGH-ACTIONABILITY- MSI-élevée / dMMR OU TMB-élevée (≥10 mut/Mb) récurrentes, persistantes, ou métastatiques parathyroïdes...