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Fludarabine

Vue déterministe de l'entité source de la LJAM. L'autorité clinique demeure avec les ID de la source cités et l'état d'approbation de l ́examinateur.

IDDRUG-FLUDARABINE
TypeMédicament
Alias
FludaraФлударабін
Étatreviewed 2026-04-25 | pending_clinical_signoff
MaladiesDIS-B-ALL DIS-DLBCL-NOS DIS-FL DIS-HGBL-DH DIS-MCL DIS-MELANOMA DIS-MM
SourcesSRC-NCCN-AML-2025 SRC-NCCN-BCELL-2025

Faits sur les drogues

CatégorieAntimétabolite analogique purine (analogique adénosine)
MécanismeFluorinated purine nucleoside analog of adenosine. Phosphorylated intracellularly to active triphosphate (F-ara-ATP); incorporated into DNA + RNA, inhibits ribonucleotide reductase + DNA primase + DNA polymerase α → S-phase arrest + apoptosis. Profoundly immunosuppressive (T-cell depletion → ideal for CAR-T lymphodepletion). Historically used in CLL (FCR), salvage lymphoma regimens, alloHCT conditioning.
Dose typiqueCAR-T lymphodepletion: 30 mg/m² IV daily × 3-4 days. CLL FCR: 25 mg/m² IV days 1-3 every 28 days × 6 cycles. Salvage lymphoma (FluMel conditioning): 30 mg/m² IV days 1-5. Renal dose adjust: CrCl 30-70 mL/min reduce 25%; CrCl <30 mL/min consider avoiding or reduce 50%.
Ukraine enregistréeVrai
NSZU rembourséVrai
Ukraine vérifiée pour la dernière fois2026-04-27

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Notes

Backbone of CAR-T lymphodepleting conditioning (Flu/Cy). Also historic CLL backbone (FCR), now largely supplanted by BTKi / BCL2i. CRITICAL: irradiate ALL blood products LIFELONG after fludarabine exposure to prevent transfusion-associated GVHD. PJP + viral prophylaxis mandatory during + ≥6 months after treatment. Renal dose adjustment essential. Ukraine: registered + НСЗУ-reimbursed.

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