Prednisone (or prednisolone equivalent)
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DRUG-PREDNISONE |
|---|---|
| Type | Drug |
| Aliases | DeltasonePrednisolonePrednisoneRayosПреднізон |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | DIS-AITL DIS-ALCL DIS-ATLL DIS-B-ALL DIS-BURKITT DIS-DLBCL-NOS DIS-EATL DIS-FL DIS-HGBL-DH DIS-HSTCL DIS-MCL DIS-NLPBL DIS-PMBCL DIS-PROSTATE DIS-PTCL-NOS DIS-PTLD |
| Sources | SRC-NCCN-BCELL-2025 |
Drug Facts
| Class | Synthetic glucocorticoid |
|---|---|
| Mechanism | Activates glucocorticoid receptors → broad anti-inflammatory, immuno- suppressive, and pro-apoptotic effects on lymphoid cells. Prodrug converted to prednisolone in liver. |
| Ukraine registered | True |
| NSZU reimbursed | True |
| Ukraine last verified | 2026-04-27 |
Notes
Equivalent to prednisolone (same active drug); used interchangeably. In R-CHOP, 5-day pulse minimizes steroid toxicity. Long-term high-dose use → PJP prophylaxis (cotrimoxazole). PPI co-prescription if GI risk factors. Glucose monitoring in diabetics.
Used By
Regimen
REG-ADT-ABIRATERONE- ADT + abiraterone + prednisone (continuous)REG-CABAZITAXEL-MCRPC- Cabazitaxel (mCRPC, 2L)REG-CHOEP- CHOEP (cyclophosphamide + doxorubicin + vincristine + etoposide + prednisone), 6 cyclesREG-CHOEP-ALLOSCT-CONSOLIDATION- Historical CHOEP / allo-HCT reference — WITHHELD FROM PLANNINGREG-CHP-BV- Brentuximab vedotin + CHP (BV-CHP), adult source-specific referenceREG-DA-EPOCH-R- Dose-adjusted EPOCH + rituximab (DA-EPOCH-R)REG-DOCETAXEL-MCRPC- Docetaxel (mCRPC)REG-MCL-INTENSIVE-RDHAP-AUTOSCT- MCL: alternating R-CHOP/R-DHAP induction followed by an ASCT pathway (MCL Younger-based)REG-POLA-R-CHP- Polatuzumab vedotin + Rituximab + CHP (Pola-R-CHP), 6 cycles + 2× rituximabREG-POMP-B-ALL-MAINTENANCE- POMP maintenance — B-ALL post-induction-consolidation (vincristine + 6-MP + MTX + prednis...REG-R-CHOP- Rituximab + CHOP (R-CHOP), 6 cycles