Prednisone (or prednisolone equivalent)

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`DRUG-PREDNISONE`
Type	Drug
Aliases	DeltasonePrednisolonePrednisoneRayosПреднізон
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-AITL` `DIS-ALCL` `DIS-ATLL` `DIS-B-ALL` `DIS-BURKITT` `DIS-DLBCL-NOS` `DIS-EATL` `DIS-FL` `DIS-HGBL-DH` `DIS-HSTCL` `DIS-MCL` `DIS-NLPBL` `DIS-PMBCL` `DIS-PROSTATE` `DIS-PTCL-NOS` `DIS-PTLD`
Sources	`SRC-NCCN-BCELL-2025`

Drug Facts

Class	Synthetic glucocorticoid
Mechanism	Activates glucocorticoid receptors → broad anti-inflammatory, immuno- suppressive, and pro-apoptotic effects on lymphoid cells. Prodrug converted to prednisolone in liver.
Ukraine registered	True
NSZU reimbursed	True
Ukraine last verified	2026-04-27

Notes

Equivalent to prednisolone (same active drug); used interchangeably. In R-CHOP, 5-day pulse minimizes steroid toxicity. Long-term high-dose use → PJP prophylaxis (cotrimoxazole). PPI co-prescription if GI risk factors. Glucose monitoring in diabetics.

Used By

Regimens

REG-ADT-ABIRATERONE - ADT + abiraterone + prednisone (continuous)
REG-CABAZITAXEL-MCRPC - Cabazitaxel (mCRPC, 2L)
REG-CHOEP - CHOEP (cyclophosphamide + doxorubicin + vincristine + etoposide + prednisone), 6 cycles
REG-CHOEP-ALLOSCT-CONSOLIDATION - CHOEP × 6 + allogeneic SCT consolidation in CR1 (fit transplant-eligible PTCL NOS)
REG-CHP-BV - Brentuximab vedotin + CHP (CHP-Bv), 6 cycles (CD30+ T-cell lymphomas)
REG-DA-EPOCH-R - Dose-Adjusted EPOCH + Rituximab (DA-EPOCH-R), 6 cycles
REG-DOCETAXEL-MCRPC - Docetaxel (mCRPC)
REG-MCL-INTENSIVE-RDHAP-AUTOSCT - Intensive 1L MCL: alternating R-CHOP / R-DHAP × 6 cycles + autoSCT consolidation + R main...
REG-POLA-R-CHP - Polatuzumab vedotin + Rituximab + CHP (Pola-R-CHP), 6 cycles + 2× rituximab
REG-POMP-B-ALL-MAINTENANCE - POMP maintenance — B-ALL post-induction-consolidation (vincristine + 6-MP + MTX + prednis...
REG-R-CHOP - Rituximab + CHOP (R-CHOP), 6 cycles