Burkitt Lymphoma
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-BURKITT |
|---|---|
| Type | Disease |
| Aliases | BLЛімфома Беркітта |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-NCCN-BCELL-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 9687/3 |
|---|---|
| icd_10 | C83.7 |
| who_classification | Aggressive B-cell lymphomas — Burkitt lymphoma per WHO 5th ed. |
Notes
Highly proliferative — risk of severe TLS at first dose. CNS prophylaxis mandatory (HD-MTX systemic + IT MTX/cytarabine). HIV testing mandatory at diagnosis. Time-sensitive but NOT "emergency-room time-critical" in CHARTER §15.2 C2 sense (treatment is outpatient/inpatient hematology pathway, not bedside emergency); we generate a Plan.
Used By
Actionability
BMA-MYC-REARRANGEMENT-BURKITT- MYC rearrangement (t(8;14) most common) is the defining genetic lesion of Burkitt lymphom...
Algorithms
ALGO-BURKITT-1L- ALGO-BURKITT-1LALGO-BURKITT-2L- ALGO-BURKITT-2L
Disease
DIS-HGBL-DH- High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double-hit / triple-hit)
Indication
IND-AUTOIMMUNE-THYROIDITIS-LYMPHOMA-PREVENTION-SURVEILLANCE- IND-AUTOIMMUNE-THYROIDITIS-LYMPHOMA-PREVENTION-SURVEILLANCEIND-BURKITT-1L-CODOX-IVAC-PROVEN-CNS- IND-BURKITT-1L-CODOX-IVAC-PROVEN-CNSIND-BURKITT-1L-CODOXM-IVAC- IND-BURKITT-1L-CODOXM-IVACIND-BURKITT-1L-DAEPOCHR- IND-BURKITT-1L-DAEPOCHRIND-BURKITT-1L-HYPERCVAD-R- IND-BURKITT-1L-HYPERCVAD-RIND-BURKITT-2L-RDHAP-ASCT- IND-BURKITT-2L-RDHAP-ASCTIND-BURKITT-2L-RICE-ASCT- IND-BURKITT-2L-RICE-ASCTIND-CHRONIC-EBV-PREVENTION-ACTIVE-SURVEILLANCE- IND-CHRONIC-EBV-PREVENTION-ACTIVE-SURVEILLANCEIND-CHRONIC-EBV-PREVENTION-CONSERVATIVE-OBSERVATION- IND-CHRONIC-EBV-PREVENTION-CONSERVATIVE-OBSERVATIONIND-IATROGENIC-TRANSPLANT-IMMUNOSUPPRESSION-PREVENTION-OBSERVATION- IND-IATROGENIC-TRANSPLANT-IMMUNOSUPPRESSION-PREVENTION-OBSERVATIONIND-IATROGENIC-TRANSPLANT-IMMUNOSUPPRESSION-PREVENTION-SURVEILLANCE- IND-IATROGENIC-TRANSPLANT-IMMUNOSUPPRESSION-PREVENTION-SURVEILLANCE
Questionnaires
QUEST-BURKITT-1L-STUB- Burkitt Lymphoma — first line
Red flag
RF-AUTOIMMUNE-THYROIDITIS-LYMPHOMA-PREVENTION- Hashimoto's thyroiditis (chronic autoimmune lymphocytic thyroiditis, positive anti-TPO an...RF-BURKITT-EMERGENCY-TLS- Burkitt lymphoma with active or imminent tumor lysis syndrome at diagnosis: LDH >2× ULN,...RF-BURKITT-FRAILTY-AGE- Frailty profile precluding intensive Burkitt regimens (CODOX-M/IVAC or DA-EPOCH-R full-do...RF-BURKITT-HIGH-RISK- Legacy Burkitt high-risk trigger for algorithm review. A fired flag alone does not establ...RF-BURKITT-IFOS-CONTRAINDICATED- Ifosfamide contraindicated or high-risk in relapsed/refractory Burkitt lymphoma 2L salvag...RF-BURKITT-INFECTION-SCREENING- Active or latent infection requiring resolution / prophylaxis before initiating DA-EPOCH-...RF-BURKITT-ORGAN-DYSFUNCTION- Baseline organ dysfunction precluding HD-MTX-containing CODOX-M/IVAC or full-dose DA-EPOC...RF-BURKITT-TRANSFORMATION-PROGRESSION- Burkitt primary-refractory (no CR after 2 cycles induction) OR early relapse <6 months po...RF-CHRONIC-EBV-MALIGNANCY-PREVENTION- Documented chronic EBV infection (positive EBV-PCR with persistently detectable viremia >...RF-IATROGENIC-TRANSPLANT-IMMUNOSUPPRESSION-PREVENTION- Chronic immunosuppression for solid-organ transplant or post-allogeneic HSCT. Elevated ri...
Sources
SRC-ESMO-BURKITT-2024- ESMO Clinical Practice Guideline on Burkitt LymphomaSRC-ESMO-LYMPHOMA-2025- Lymphomas: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-upSRC-MOZ-UA-LYMPH-2013- Уніфікований клінічний протокол первинної, вторинної (спеціалізованої) медичної допомоги:...