Post-Transplant Lymphoproliferative Disorder
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-PTLD |
|---|---|
| Type | Disease |
| Aliases | Allograft-associated LPDPTLDPost-transplant lymphomaПосттрансплантаційні лімфопроліферативні захворювання |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-NCCN-BCELL-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 9971/3 |
|---|---|
| icd_10 | D47.Z1 |
| who_classification | Lymphoid proliferations and lymphomas associated with immunodeficiency — Post-transplant lymphoproliferative disorders per WHO 5th ed. (4 categories: non-destructive, polymorphic, monomorphic, classical Hodgkin-like) |
Notes
STUB. Multi-disciplinary — обов'язкова transplant team consultation перед IS reduction. EBV viral load PCR + EBER ISH for tumor — diagnostic. Solid organ transplant-specific: graft rejection ризик при IS reduction → balance.
Used By
Actionability
BMA-MYD88-L265P-PTLD- MYD88 L265P uncommon in PTLD. Standard PTLD ladder (RIS → rituximab → R-CHOP) per usual a...
Algorithms
ALGO-PTLD-1L- ALGO-PTLD-1LALGO-PTLD-2L- ALGO-PTLD-2L
Disease
DIS-PCNSL- Primary Diffuse Large B-Cell Lymphoma of the CNS
Indication
IND-PTLD-1L-RCHOP- IND-PTLD-1L-RCHOPIND-PTLD-1L-REDUCE-IS- IND-PTLD-1L-REDUCE-ISIND-PTLD-MAINTENANCE-RITUXIMAB- IND-PTLD-MAINTENANCE-RITUXIMAB
Questionnaires
QUEST-PTLD-1L-STUB- Post-Transplant Lymphoproliferative Disorder — first line
Red flag
RF-IATROGENIC-TRANSPLANT-IMMUNOSUPPRESSION-LONGTERM-PREVENTION- Solid-organ transplant recipient on chronic immunosuppression ≥3 years post-transplant, b...RF-PTLD-FRAILTY-AGE- Age >70 + advanced organ dysfunction OR ECOG ≥3 — full-dose R-CHOP poorly tolerated; redu...RF-PTLD-HIGH-RISK-BIOLOGY- Monomorphic PTLD with DLBCL-type morphology / Burkitt-like / T-cell PTLD — chemoimmunothe...RF-PTLD-INFECTION-SCREENING- EBV viral load + CMV PCR mandatory; EBV-driven PTLD (most cases) responds to rituximab ±...RF-PTLD-ORGAN-DYSFUNCTION- Allograft dysfunction (worsening creatinine if kidney, transaminases if liver, troponin i...RF-PTLD-TRANSFORMATION-PROGRESSION- Failure of IS-reduction trial after 2-4 weeks (no clinical/radiologic improvement) — esca...