Small cell lung cancer
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-SCLC |
|---|---|
| Type | Disease |
| Aliases | SCLCДРЛДрібноклітинний рак легені |
| Status | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-ESMO-SCLC-2021 SRC-NCCN-SCLC-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 8041/3 |
|---|---|
| icd_o_3_topography | ["C34.9"] |
| icd_10 | C34 |
| who_classification | Small cell lung carcinoma — neuroendocrine tumor (WHO 5th 2021) |
Notes
archetype: stage_driven — limited vs extensive is the dominant fork. Modern era: chemoimmunotherapy combinations standard for extensive; chemo + concurrent RT for limited. Targeted/biomarker-driven options (e.g., DLL3-targeted tarlatamab for extensive 2L+) emerging but not yet 1L standard.
Used By
Actionability
BMA-RB1-SCLC- RB1 biallelic loss, together with TP53 loss, is the molecular hallmark of SCLC (~95% of c...BMA-TP53-MUT-SCLC- TP53 mutation in SCLC — common, adverse prognostic; not directly targeted. Per usual algo...
Algorithms
ALGO-SCLC-1L- ALGO-SCLC-1LALGO-SCLC-2L- ALGO-SCLC-2L
Disease
DIS-NSCLC- Non-small cell lung cancer
Indication
IND-SCLC-EXTENSIVE-1L- IND-SCLC-EXTENSIVE-1LIND-SCLC-LIMITED-1L- IND-SCLC-LIMITED-1LIND-SCLC-LS-CONSOLIDATION-DURVA- IND-SCLC-LS-CONSOLIDATION-DURVAIND-SCLC-PLATINUM-RECHALLENGE- IND-SCLC-PLATINUM-RECHALLENGEIND-SCLC-RR-LURBINECTEDIN- IND-SCLC-RR-LURBINECTEDININD-SCLC-RR-TARLATAMAB- IND-SCLC-RR-TARLATAMABIND-SCLC-RR-TOPOTECAN- IND-SCLC-RR-TOPOTECAN
Questionnaires
QUEST-SCLC-1L-STUB- Small cell lung cancer — first line
Red flag
RF-LIFESTYLE-TOBACCO-CANCER-PREVENTION- Active tobacco smoking (current smoker OR cessation <15 years) OR smokeless tobacco use O...RF-OCC-ASBESTOS-MALIGNANCY-PREVENTION- Documented historical occupational exposure to asbestos fibres (chrysotile, amosite, croc...RF-OCC-DIESEL-EXHAUST-PREVENTION- Documented historical occupational exposure to diesel-engine exhaust (DEE) — typical high...RF-OCC-FIREFIGHTER-PREVENTION- Documented historical occupational exposure as a career firefighter (≥10 years in active...RF-OCC-IONIZING-RADIATION-PREVENTION- Documented historical occupational exposure to ionizing radiation — typical high-risk occ...RF-OCC-PAH-PREVENTION- Documented historical occupational exposure to polycyclic aromatic hydrocarbons (PAHs) —...RF-OCC-PAINTERS-PREVENTION- Documented historical occupational exposure as a painter — typical high-risk roles includ...RF-OCC-SILICA-PREVENTION- Documented historical occupational exposure to respirable crystalline silica (RCS; α-quar...RF-RADON-MALIGNANCY-PREVENTION- Documented elevated radon exposure — either residential (indoor-air radon ≥4 pCi/L per EP...RF-SCLC-BRAIN-METS-EMERGENCY- SCLC with symptomatic brain metastases requiring emergency intervention: focal deficit, n...RF-SCLC-FRAILTY-AGE- Age ≥75 + ECOG ≥2 OR significant comorbidity — concurrent CRT (limited-stage) poorly tole...RF-SCLC-HIGH-RISK-BIOLOGY- High-risk biological features in SCLC: extensive-stage at presentation (ES-SCLC, ~70% of...RF-SCLC-INFECTION-SCREENING- Active or latent infection requiring resolution / prophylaxis before initiating platinum-...RF-SCLC-ORGAN-DYSFUNCTION- Renal dysfunction (CrCl <50) OR severe hepatic impairment — limits cisplatin (use carbopl...RF-SCLC-PARANEOPLASTIC- Paraneoplastic syndrome (SIADH, Cushing's, Lambert-Eaton, autoimmune limbic encephalitis)...RF-SCLC-SVC-SYNDROME- Small-cell lung cancer with superior vena cava syndrome: facial/upper-extremity edema, di...
Regimen
REG-CE-SCLC- Carboplatin + etoposide (SCLC, 1L)REG-TOPOTECAN-SCLC-RR- Topotecan (SCLC relapsed/refractory)
Sources
SRC-ADRIATIC-CHENG-2024- Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung CancerSRC-DELLPHI-301-AHN-2023- Tarlatamab for Patients with Previously Treated Small-Cell Lung CancerSRC-ESMO-SCLC-2021- ESMO Clinical Practice Guideline on Small Cell Lung CancerSRC-NCCN-SCLC-2025- NCCN Clinical Practice Guidelines — Small Cell Lung Cancer