Documented elevated radon exposure — either residential (indoor-air radon ≥4 pCi/L per EP...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-RADON-MALIGNANCY-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-NSCLC` `DIS-SCLC`
Sources	`SRC-ESMO-NSCLC-EARLY-2024` `SRC-NCCN-NSCLC-2025` `SRC-NCCN-SCLC-2025`

Red Flag Origin

Definition	Documented elevated radon exposure — either residential (indoor-air radon ≥4 pCi/L per EPA action threshold, or ≥148 Bq/m³ per WHO threshold; geographic high-risk areas with documented home measurement) or occupational (uranium / hard-rock mining, milling and processing; underground non-uranium mining with documented radon-progeny exposure; pre-regulation occupations) — in an individual without a current lung-cancer diagnosis. Radon (²²²Rn) and its short-lived progeny (²¹⁸Po, ²¹⁴Pb, ²¹⁴Bi, ²¹⁴Po) emit alpha radiation that deposits in bronchial epithelium when inhaled. Radon is an IARC Group 1 carcinogen — the second-leading cause of lung cancer overall after tobacco smoking, and the leading cause among never-smokers. Radon-smoking interaction is synergistic (greater than additive but submultiplicative on the log-additive scale), with smoker- radon-exposed workers carrying ~10-25x backgr...
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "residential_radon_exposure_ge_4_pci_per_l",
      "value": true
    },
    {
      "finding": "residential_radon_exposure_documented_high_with_smoking_hx",
      "value": true
    },
    {
      "finding": "occupational_uranium_mining_or_processing_exposure",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag — v0.3 occupational/environmental pilot starter. Mixed occupational-and-residential scope: the same risk-category enum value (`occupational`) covers both per KSS §20.1 7-category taxonomy (the taxonomy has no separate ENVIRONMENTAL bucket — radon's residential-exposure context is treated as occupational-equivalent for routing). Fires when patient profile carries documented elevated radon exposure (residential at-or-above EPA action level, or documented high residential with smoking history, or occupational uranium-mining / processing exposure) AND no confirmed lung-cancer diagnosis. Engine routes to a 2-track PreventionPlan: (a) IND-RADON-PREVENTION-MITIGATION-AND-SCREENING (standard) — radon mitigation (sub-slab depressurization, ventilation, sealing) for residential exposure; smoking- cessation counseling (synergistic with radon for lung cancer); annual LDCT per modified USPSTF criteria adjusted for radon-elevated risk. (b) IND-RADON-PREVENTION-OBSERVATION (surveillance) — unmodified USPSTF screening criteria only; patient declines intensified imaging surveillance and / or radon mitigation. Evidence base (IARC Monograph 100D 2012; BEIR VI Report 1999;...

Used By

Indications

IND-RADON-PREVENTION-MITIGATION-AND-SCREENING - IND-RADON-PREVENTION-MITIGATION-AND-SCREENING
IND-RADON-PREVENTION-OBSERVATION - IND-RADON-PREVENTION-OBSERVATION