Paraneoplastic syndrome (SIADH, Cushing's, Lambert-Eaton, autoimmune limbic encephalitis)...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-SCLC-PARANEOPLASTIC`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-SCLC`
Sources	`SRC-ESMO-SCLC-2021` `SRC-NCCN-SCLC-2025`

Red Flag Origin

Definition	Paraneoplastic syndrome (SIADH, Cushing's, Lambert-Eaton, autoimmune limbic encephalitis) — common in SCLC; neurology / endocrinology consult; symptomatic management may delay or modify systemic therapy initiation.
Clinical direction	investigate
Category	transformation-progression

Trigger Logic

{
  "any_of": [
    {
      "finding": "siadh",
      "value": true
    },
    {
      "finding": "cushing_paraneoplastic",
      "value": true
    },
    {
      "finding": "lambert_eaton",
      "value": true
    },
    {
      "finding": "limbic_encephalitis",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Paraneoplastic syndromes affect ~15-25% of SCLC patients. Tumor control often resolves the syndrome; severe presentations may require pre-systemic-therapy stabilization.

Used By

Indications

IND-SCLC-RR-LURBINECTEDIN - IND-SCLC-RR-LURBINECTEDIN
IND-SCLC-RR-TARLATAMAB - IND-SCLC-RR-TARLATAMAB
IND-SCLC-RR-TOPOTECAN - IND-SCLC-RR-TOPOTECAN