Age ≥75 + ECOG ≥2 OR significant comorbidity — concurrent CRT (limited-stage) poorly tole...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | RF-SCLC-FRAILTY-AGE |
|---|---|
| Type | Red flag |
| Status | pending_clinical_signoff |
| Diseases | DIS-SCLC |
| Sources | SRC-ESMO-SCLC-2021 SRC-NCCN-SCLC-2025 |
Red Flag Origin
| Definition | Age ≥75 + ECOG ≥2 OR significant comorbidity — concurrent CRT (limited-stage) poorly tolerated; sequential CRT or single-agent palliative chemo considered. |
|---|---|
| Clinical direction | de-escalate |
| Category | frailty-age |
Trigger Logic
{
"all_of": [
{
"comparator": ">=",
"finding": "age_years",
"threshold": 75
},
{
"any_of": [
{
"comparator": ">=",
"finding": "ecog_status",
"threshold": 2
},
{
"comparator": ">=",
"finding": "comorbidity_count",
"threshold": 2
}
]
}
],
"type": "composite_clinical"
}
Notes
Limited-stage SCLC + frailty: sequential CRT (chemo first, then RT) better tolerated than concurrent. Extensive-stage + frailty: EP + ICI feasible with G-CSF support.
Used By
Algorithms
ALGO-SCLC-1L- ALGO-SCLC-1L
Indications
IND-SCLC-EXTENSIVE-1L- IND-SCLC-EXTENSIVE-1LIND-SCLC-LIMITED-1L- IND-SCLC-LIMITED-1L