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Age ≥75 + ECOG ≥2 OR significant comorbidity — concurrent CRT (limited-stage) poorly tole...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-SCLC-FRAILTY-AGE
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-SCLC
SourcesSRC-ESMO-SCLC-2021 SRC-NCCN-SCLC-2025

Red Flag Origin

DefinitionAge ≥75 + ECOG ≥2 OR significant comorbidity — concurrent CRT (limited-stage) poorly tolerated; sequential CRT or single-agent palliative chemo considered.
Clinical directionde-escalate
Categoryfrailty-age

Trigger Logic

{
  "all_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 75
    },
    {
      "any_of": [
        {
          "comparator": ">=",
          "finding": "ecog_status",
          "threshold": 2
        },
        {
          "comparator": ">=",
          "finding": "comorbidity_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite_clinical"
}

Notes

Limited-stage SCLC + frailty: sequential CRT (chemo first, then RT) better tolerated than concurrent. Extensive-stage + frailty: EP + ICI feasible with G-CSF support.

Used By

Algorithms

Indications