Renal dysfunction (CrCl <50) OR severe hepatic impairment — limits cisplatin (use carbopl...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-SCLC-ORGAN-DYSFUNCTION`
Type	Red flag
Status	pending_clinical_signoff
Diseases	`DIS-SCLC`
Sources	`SRC-ESMO-SCLC-2021` `SRC-NCCN-SCLC-2025`

Red Flag Origin

Definition	Renal dysfunction (CrCl <50) OR severe hepatic impairment — limits cisplatin (use carboplatin AUC 5); dose-modify etoposide for liver impairment.
Clinical direction	investigate
Category	organ-dysfunction

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "creatinine_clearance_ml_min",
      "threshold": 50
    },
    {
      "finding": "child_pugh_class",
      "value": "C"
    }
  ],
  "type": "composite_clinical"
}

Notes

Carboplatin substitution standard for CrCl <50. Liver dysfunction: reduce etoposide 50% if bilirubin 1.5-3x ULN; avoid if >3x ULN.

Used By

Indications

IND-SCLC-RR-LURBINECTEDIN - IND-SCLC-RR-LURBINECTEDIN
IND-SCLC-RR-TARLATAMAB - IND-SCLC-RR-TARLATAMAB
IND-SCLC-RR-TOPOTECAN - IND-SCLC-RR-TOPOTECAN