PD-L1 Combined Positive Score (CPS)
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BIO-PDL1-CPS |
|---|---|
| Type | Biomarker |
| Aliases | CPSPD-L1 CPS |
| Status | reviewed 2026-04-26 |
| Diseases | None declared |
| Sources | SRC-NCCN-ESOPHAGEAL-2025 SRC-NCCN-GASTRIC-2025 |
Biomarker Facts
| Biomarker type | protein_expression_ihc |
|---|---|
| Measurement | MethodIHC 22C3 pharmDx; CPS = (PD-L1+ cells [tumor + lymphocytes + macrophages] / total tumor cells) × 100 UnitsCPS score (numeric, ≥0) |
| Related biomarkers | BIO-PDL1-EXPRESSION |
Used By
Actionability
BMA-PDL1-CPS-CERVICAL- PD-L1 CPS ≥1 is required for pembrolizumab in persistent/recurrent/metastatic cervical ca...BMA-PDL1-CPS-ESOPHAGEAL- PD-L1 CPS used as eligibility threshold for ICI in metastatic esophageal cancer. Esophage...BMA-PDL1-CPS-GASTRIC- PD-L1 CPS is a continuous IHC score used as an eligibility threshold for ICI-containing r...BMA-PDL1-CPS-HNSCC- PD-L1 CPS is the primary predictive biomarker for pembrolizumab in recurrent/metastatic H...
Biomarker
BIO-CLDN18-2- Claudin-18.2 expression (CLDN18.2)BIO-PDL1-22C3-CLONE- PD-L1 IHC — Dako 22C3 pharmDx clone
Diseases
DIS-HNSCC- Head and neck squamous cell carcinoma (HNSCC)
Indications
IND-BREAST-TNBC-METASTATIC-1L-PEMBRO-CHEMO- IND-BREAST-TNBC-METASTATIC-1L-PEMBRO-CHEMOIND-ESOPH-METASTATIC-1L-SCC-IPI-NIVO- IND-ESOPH-METASTATIC-1L-SCC-IPI-NIVOIND-ESOPH-METASTATIC-2L-PEMBRO-CPS10- IND-ESOPH-METASTATIC-2L-PEMBRO-CPS10IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICI- IND-GASTRIC-METASTATIC-1L-PDL1-CHEMO-ICIIND-HNSCC-RM-1L-EXTREME- IND-HNSCC-RM-1L-EXTREMEIND-HNSCC-RM-1L-PEMBRO-CHEMO- IND-HNSCC-RM-1L-PEMBRO-CHEMOIND-HNSCC-RM-1L-PEMBRO-MONO-CPS-HIGH- IND-HNSCC-RM-1L-PEMBRO-MONO-CPS-HIGH
Questionnaires
QUEST-ESOPHAGEAL-1L-STUB- Esophageal carcinoma — first lineQUEST-GASTRIC-1L-STUB- Gastric and gastroesophageal junction adenocarcinoma — first lineQUEST-HNSCC-1L-STUB- Head and neck squamous cell carcinoma — first line
Red flag
RF-CERVICAL-PDL1-CPS-1-PLUS- Persistent, recurrent, or metastatic cervical cancer with PD-L1 CPS ≥1 by 22C3 IHC. KEYNO...RF-GASTRIC-PDL1-CPS-1-PLUS- Advanced/metastatic gastric or GE-junction adenocarcinoma with PD-L1 combined positive sc...