Vulvar and vaginal squamous cell carcinoma
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-VULVAR-VAGINAL-SCC |
|---|---|
| Type | Disease |
| Aliases | HPV-associated vulvar SCCLichen-sclerosus-derived SCCVIN-derived SCCVaginal SCCVulvar SCCПлоскоклітинна карцинома вульви та піхви |
| Status | reviewed 2026-05-18 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-IARC-MONO-100B-2012 SRC-NCCN-CERVICAL-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 8070/3 |
|---|---|
| icd_o_3_topography | ["C51", "C52"] |
| icd_10 | C51, C52 |
| who_classification | WHO Female Genital Tumours 5th ed (2020): Vulvar SCC (HPV-associated + HPV-independent) and Vaginal SCC |
Notes
Two biological subgroups managed similarly anatomically but with distinct prevention implications: HPV-driven (vaccination prevents precursor lesions; screening with vulvar exam + biopsy of any persistent lesion) vs HPV-independent (lichen sclerosus surveillance is the dominant prevention modality; topical clobetasol may reduce malignant transformation in select cohorts). Treatment: early-stage — wide local excision ± inguinal sentinel node biopsy (GROINSS-V paradigm replacing routine complete inguinofemoral lymphadenectomy); locally advanced — definitive chemoradiation (cisplatin + RT); metastatic — pembrolizumab if PD-L1+ (KEYNOTE-158 cohort). Vaginal SCC managed similarly with RT-based approaches (anatomic constraints limit surgical options).
Used By
Algorithms
ALGO-VULVAR-VAGINAL-SCC-1L- ALGO-VULVAR-VAGINAL-SCC-1L
Disease
DIS-PENILE-SCC- Penile squamous cell carcinoma
Indication
IND-IATROGENIC-DES-EXPOSURE-PREVENTION-OBSERVATION- IND-IATROGENIC-DES-EXPOSURE-PREVENTION-OBSERVATIONIND-IATROGENIC-DES-EXPOSURE-PREVENTION-SURVEILLANCE- IND-IATROGENIC-DES-EXPOSURE-PREVENTION-SURVEILLANCEIND-VULVAR-VAGINAL-SCC-1L-WLE-SLNB- IND-VULVAR-VAGINAL-SCC-1L-WLE-SLNBIND-VULVAR-VAGINAL-SCC-LA-1L-CISPLATIN-RT- IND-VULVAR-VAGINAL-SCC-LA-1L-CISPLATIN-RTIND-VULVAR-VAGINAL-SCC-METASTATIC-1L-PEMBRO- IND-VULVAR-VAGINAL-SCC-METASTATIC-1L-PEMBRO
Red flag
RF-IATROGENIC-DES-EXPOSURE-PREVENTION- In-utero exposure to diethylstilbestrol (DES), a synthetic non- steroidal estrogen prescr...RF-REPRODUCTIVE-DES-IN-UTERO-EXPOSURE-PREVENTION- In-utero exposure to diethylstilbestrol (DES) — synthetic non-steroidal estrogen prescrib...RF-VULVAR-VAGINAL-SCC-PDL1-CPS-1-PLUS- Previously treated, recurrent, or metastatic vulvar or vaginal squamous cell carcinoma wi...
Sources
SRC-GROINSS-V-VANDERZEE-2008- Sentinel Node Dissection Is Safe in the Treatment of Early-Stage Vulvar Cancer (GROINSS-V...SRC-KEYNOTE-158-VULVAR-SHAPIRA-FROMMER-2022- Efficacy and Safety of Pembrolizumab for Patients With Previously Treated Advanced Vulvar...