Laryngeal squamous cell carcinoma
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-LARYNGEAL |
|---|---|
| Type | Disease |
| Aliases | Cancer of the larynxGlottic cancerLaryngeal SCCLaryngeal cancerSubglottic cancerSupraglottic cancerПлоскоклітинна карцинома гортані |
| Status | reviewed 2026-05-18 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-IARC-MONO-100B-2012 SRC-NCCN-HNSCC-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 8070/3 |
|---|---|
| icd_o_3_topography | ["C32"] |
| icd_10 | C32 |
| who_classification | WHO Head and Neck Tumours 5th ed (2022): Laryngeal squamous cell carcinoma (glottic / supraglottic / subglottic subsites) |
Notes
Three subsites with distinct biology and treatment patterns. Early glottic (T1-T2N0): radiation OR transoral laser microsurgery (TLM) — both ~90% local control with voice preservation as key endpoint. Locally advanced: larynx-preservation chemoradiation (cisplatin + RT) per RTOG 91-11 / VA-trial paradigm vs total laryngectomy + postoperative RT — patient preference / fitness drives choice. Recurrent / metastatic: pembrolizumab ± chemo per KEYNOTE-048 (same framework as broader HNSCC). Smoking cessation surveillance dominates prevention narrative.
Used By
Algorithms
ALGO-LARYNGEAL-1L- ALGO-LARYNGEAL-1L
Indication
IND-LARYNGEAL-EARLY-GLOTTIC-1L-RT- IND-LARYNGEAL-EARLY-GLOTTIC-1L-RTIND-LARYNGEAL-EARLY-GLOTTIC-1L-TLM- IND-LARYNGEAL-EARLY-GLOTTIC-1L-TLMIND-LARYNGEAL-LA-1L-CRT- IND-LARYNGEAL-LA-1L-CRTIND-LARYNGEAL-LA-1L-TOTAL-LARYNGECTOMY- IND-LARYNGEAL-LA-1L-TOTAL-LARYNGECTOMYIND-LARYNGEAL-RM-1L-EXTREME- IND-LARYNGEAL-RM-1L-EXTREMEIND-LARYNGEAL-RM-1L-PEMBRO-CHEMO- IND-LARYNGEAL-RM-1L-PEMBRO-CHEMOIND-LARYNGEAL-RM-1L-PEMBRO-MONO-CPS-HIGH- IND-LARYNGEAL-RM-1L-PEMBRO-MONO-CPS-HIGH
Procedures
SUR-LARYNGEAL-TLM- Transoral laser microsurgery (TLM) for early glottic carcinomaSUR-LARYNGEAL-TOTAL-LARYNGECTOMY- Total laryngectomy
Red flag
RF-LARYNGEAL-POOR-PRESERVATION-CANDIDACY- Feature precluding larynx-preservation chemoradiation (RTOG 91-11 concurrent cisplatin +...
Sources
SRC-KEYNOTE-048-BURTNESS-2019- Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent...SRC-RTOG-9111-FORASTIERE-2003- Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Can...