Breast cancer (invasive) · line 1 · Pembrolizumab + chemotherapy (TNBC, metastatic PD-L1+)
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
Knowledge-base record for audit. Provisional clinical content: this is not a prescription. An oncologist must verify original sources, applicability and review status. Full rules and constraints are in the YAML.
| Line of therapy | 1 |
|---|---|
| Track | standard |
| Linked regimen | REG-PEMBRO-CHEMO-TNBC-MET |
| ID | IND-BREAST-TNBC-METASTATIC-1L-PEMBRO-CHEMO |
|---|---|
| Type | Indication |
| Status | reviewed 2026-05-04 | pending_clinical_signoff |
| Diseases | DIS-BREAST |
| Sources | SRC-KEYNOTE-355-CORTES-2020 |
Notes
ATEZOLIZUMAB WARNING: Do NOT use atezolizumab+nab-paclitaxel for mTNBC. FDA withdrew the atezolizumab mTNBC indication August 2021 because IMPASSION131 (paclitaxel backbone) failed to confirm OS benefit from IMPASSION130 (nab-paclitaxel backbone). The mechanism is that paclitaxel + nab-paclitaxel may have different immune interaction profiles. Any remaining KB entries referencing atezolizumab for mTNBC 1L are legacy/historical. SACITUZUMAB GOVITECAN in mTNBC 1L: ASCENT trial established sacituzumab as a standard-of-care option for 2L+ (≥2 prior lines), not currently 1L. TROPiCS-02 established 2L pembro-refractory setting. 1L status for sacituzumab not yet established.
Used By
Algorithms
ALGO-BREAST-1L- ALGO-BREAST-1L