MYC rearrangement (8q24) by FISH break-apart
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BIO-MYC-REARRANGEMENT |
|---|---|
| Type | Biomarker |
| Aliases | MYC rearrangementMYC rearrangement (8q24) — FISH break-apart |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-NCCN-BCELL-2025 |
Biomarker Facts
| Biomarker type | gene_fusion |
|---|---|
| Measurement | MethodFISH break-apart probe on FFPE biopsy Unitscategorical (positive | negative) |
| Related biomarkers | None declared |
Notes
Defining feature of Burkitt lymphoma (~95-100%); also seen in high-grade B-cell lymphoma double-hit (~10-15% of DLBCL, with concurrent BCL2 or BCL6 rearrangement). Distinguishing Burkitt from HGBL-DH: MYC + Ki67 ~100% + characteristic morphology + flow markers (CD10+, CD19+, BCL2−). HGBL-DH has Ki67 typically lower + BCL2+.
Used By
Actionability
BMA-MYC-REARRANGEMENT-BURKITT- MYC rearrangement (t(8;14) most common) is the defining genetic lesion of Burkitt lymphom...BMA-MYC-REARRANGEMENT-DLBCL-NOS- Isolated MYC rearrangement in DLBCL (without BCL2/BCL6) — adverse prognostic but not equi...BMA-MYC-REARRANGEMENT-FL- MYC rearrangement acquired in FL signals transformation to HGBL/DLBCL — change therapy to...BMA-MYC-REARRANGEMENT-NLPBL- MYC rearrangement in nodular lymphocyte-predominant B-cell lymphoma is rare and typically...
Biomarker
BIO-BCL2-REARRANGEMENT- BCL2 rearrangement (t(14;18) IGH/BCL2 by FISH break-apart)BIO-BCL6-IHC- BCL6 IHC (protein expression)BIO-BCL6-REARRANGEMENT- BCL6 rearrangement (3q27) by FISH break-apartBIO-DOUBLE-HIT- Double-hit (MYC + BCL2 and/or BCL6 rearrangements)
Indications
IND-BURKITT-1L-CODOXM-IVAC- IND-BURKITT-1L-CODOXM-IVACIND-BURKITT-1L-DAEPOCHR- IND-BURKITT-1L-DAEPOCHRIND-BURKITT-1L-HYPERCVAD-R- IND-BURKITT-1L-HYPERCVAD-RIND-BURKITT-2L-RDHAP-ASCT- IND-BURKITT-2L-RDHAP-ASCTIND-BURKITT-2L-RICE-ASCT- IND-BURKITT-2L-RICE-ASCTIND-HGBL-DH-1L-DAEPOCHR- IND-HGBL-DH-1L-DAEPOCHRIND-HGBL-DH-1L-RCHOP- IND-HGBL-DH-1L-RCHOP
Questionnaires
QUEST-BURKITT-1L-STUB- Burkitt Lymphoma — first lineQUEST-HGBL-DH-1L-STUB- High-Grade B-Cell Lymphoma, Double-Hit / Triple-Hit — first line