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Carcinoma cervical (predominante escamoso + adeno)

Visão determinística da entidade fonte YAML. A autoridade clínica permanece com os IDs de fonte citados e estado de assinatura do revisor.

IDDIS-CERVICAL
TipoDoença
Alegais
Carcinoma cervicalCarcinoma de útero do úter do úlceroКарцинома шийки матки
Estadoreviewed 2026-04-26 | pending_clinical_signoff
DoençasNenhuma declaração
FontesSRC-ESMO-CERVICAL-2024 SRC-NCCN-CERVICAL-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Fonte YAML

icd_o_3_morphology8070/3
icd_o_3_topography["C53"]
icd_10C53
who_classificationWHO Female Genital Tumours 5th ed (2020): Cervical squamous cell carcinoma + cervical adenocarcinoma

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Scaffolded for batch #2: focus on locally-advanced (FIGO IB3-IVA) CRT and metastatic 1L systemic. Cervical is the second etiologically_driven disease in KB (after HCV-MZL); HPV is the near-universal causal agent. 4 RFs: hydronephrosis-from-pelvic-mass (organ-dysfunction emergency), HIV-coinfection (infection-screening + prognostic), bulky-disease (high-risk biology), frailty/age. Regimens: cisplatin-radiosensitization (concurrent CRT), pembro+chemo+bev (KEYNOTE-826 metastatic), tisotumab vedotin (innovaTV-301 2L+). Out-of-scope this commit: early-stage IA1-IB2 conservative surgery (cone, simple/modified-radical hysterectomy) — Surgery entity per PROPOSAL §17 needed; brachytherapy as separate modality.

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