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Carcinoma de células esquamosas vaginais e vulvares

Visão determinística da entidade fonte YAML. A autoridade clínica permanece com os IDs de fonte citados e estado de assinatura do revisor.

IDDIS-VULVAR-VAGINAL-SCC
TipoDoença
Alegais
CSC de vulvar associado ao HPVCCC derivado de esclerosio de líquenCSC derivado de VINAvaliação da capacidade de produção de energiaAvaliação da capacidade de produçãoПлоскоклітинна карцинома вульви та піхви
Estadoreviewed 2026-05-18 | pending_clinical_signoff
DoençasNenhuma declaração
FontesSRC-IARC-MONO-100B-2012 SRC-NCCN-CERVICAL-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Fonte YAML

icd_o_3_morphology8070/3
icd_o_3_topography["C51", "C52"]
icd_10C51, C52
who_classificationWHO Female Genital Tumours 5th ed (2020): Vulvar SCC (HPV-associated + HPV-independent) and Vaginal SCC

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Two biological subgroups managed similarly anatomically but with distinct prevention implications: HPV-driven (vaccination prevents precursor lesions; screening with vulvar exam + biopsy of any persistent lesion) vs HPV-independent (lichen sclerosus surveillance is the dominant prevention modality; topical clobetasol may reduce malignant transformation in select cohorts). Treatment: early-stage — wide local excision ± inguinal sentinel node biopsy (GROINSS-V paradigm replacing routine complete inguinofemoral lymphadenectomy); locally advanced — definitive chemoradiation (cisplatin + RT); metastatic — pembrolizumab if PD-L1+ (KEYNOTE-158 cohort). Vaginal SCC managed similarly with RT-based approaches (anatomic constraints limit surgical options).

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