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Gastroenteropankreas neuroendokriner Tumor — GI-Ursprung (Karzinoid), gut differenziert G1/G2

Deterministische Ansicht der Quelle YAML Entität. Klinische Autorität bleibt mit den zitierten Quell-IDs und Rezensenten Sign-off Zustand.

IDDIS-GI-NET
ArtErkrankung
Aliase
Anhang NETKarzinoider Tumor (Mittegut)GEP-NET (nichtpankreatisch)Neuroendokriner Tumor (Karzinoid)GI-NETIlealkarzinoidRektale NETDünndarm-NETZГастроентеропанкреатична нейроендокринна пухлина — ШКТ походження (карциноїд), добре-диференційована G1/G2
Statusreviewed 2026-05-03 | pending_clinical_signoff
ErkrankungenNone declared
QuellenSRC-NCCN-NET-2025

Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.

Quelle: YAML

icd_o_3_morphology8240/3
icd_o_3_topography["C17", "C18", "C19", "C20", "C18.1"]
icd_10C17.9
who_classificationWHO-Klassifikation für Verdauungssystem Tumore 5th ed (2019): Gut differenzierter neuroendokriner Tumor des Dünndarms/Appendix/kolon/rectum G1/G2

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Anmerkungen

GI-NET (non-pancreatic) is the most common NET overall. Midgut/ileal carcinoids are prototypical: indolent growth, somatostatin receptor expression (SSTR2+), liver/mesenteric metastases, carcinoid syndrome (serotonin-driven flushing + diarrhea). Grading per WHO 2019: G1 Ki67 <3%, G2 Ki67 3–20%. Carcinoid syndrome occurs when serotonin (and other mediators) bypass hepatic metabolism — typically with liver metastases or retroperitoneal disease. SSA (octreotide/lanreotide) are the foundation of treatment: (1) symptom control and (2) antiproliferative (CLARINET, PROMID). PRRT (¹⁷⁷Lu-DOTATATE; NETTER-1 trial, Strosberg NEJM 2017) is approved for SSTR2+ midgut NETs after SSA progression — pending KB SSTR biomarker scaffolding (deferred). Key trials: CLARINET (lanreotide, Caplin NEJM 2014), PROMID (octreotide LAR, Rinke JCO 2009), NETTER-1 (PRRT, Strosberg NEJM 2017).

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