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OpenOnco · Diagnostic · Multi-system suspicion · Renal mass + atypical melanocytic + endometrial thickening
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OpenOnco · Workup Brief · DIAGNOSTIC PHASE
Pre-tumor-board workup brief
DPLAN-PZ-DIAG-MULTI-001-V1 · v1 · 2026-05-12
Patient
PZ-DIAG-MULTI-001 · suspicion lineage: solid_tumor_kidney_rcc
Tissues: kidney, skin, endometrium · Hypotheses: DIS-RCC, DIS-MELANOMA, DIS-ENDOMETRIAL
56F postmenopausal × 4 yrs presents with multi-system concerning findings discovered during workup of unrelated symptoms: (1) Workup of microscopic hematuria revealed 4.0 cm contrast-enhancing exophytic kidney_mass right upper pole on CT (RENAL nephrometry 8); (2) Routine dermatology screening identified atypical pigmented growth on dorsal foot 1.1 cm with ABCDE positive (asymmetry + irregular border + variegated color + diameter + recent enlargement) — melanoma_suspect; (3) TVUS during postmenopausal cervical screening showed endometrial_thickening 12 mm without clinical symptoms (no PMB) — endometrial workup also indicated. PCP appropriately concerned for synchronous multi-primary cancers vs metastatic disease vs hereditary cancer syndrome. No family history of specific cancers but limited family knowledge. Workup needs coordinated biopsy planning across 3 sites + germline panel for multi-cancer susceptibility (BAP1, BRCA1/2, HRR, Lynch).

Workup steps (1)

MDT brief

Discussion questions (1, 0 blocking)

  • DQ-DIFFERENTIAL
    What is the differential diagnosis plan between hypotheses: DIS-RCC, DIS-MELANOMA, DIS-ENDOMETRIAL? Which molecular / IHC tests differentiate them?
    Multiple hypotheses — must be differentiated before treatment discussion.
    → pathologist

MDT talk tree (3 steps)

#OwnerTopicAction
1pathologistPathology confirmation What is the differential diagnosis plan between hypotheses: DIS-RCC, DIS-MELANOMA, DIS-ENDOMETRIAL? Which molecular / IHC tests differentiate them?
2radiologistSpecialist review Stage / restaging imaging + biopsy guidance — radiologist.
3surgical_oncologistSpecialist review Suspected solid tumor — resectability assessment, biopsy approach.

Skills (required) — mandatory virtual specialists (2)

  • Pathologist (general) required
    Any suspicion requires biopsy — pathologist plans site selection, IHC panel, ancillary tests.
    Owns: DQ-DIFFERENTIAL
  • Radiologist required
    Stage / restaging imaging + biopsy guidance — radiologist.

Skills (recommended) — for consideration (1)

  • Surgical oncologist recommended
    Suspected solid tumor — resectability assessment, biopsy approach.
Technical MDT skill metadata (3/16 activated in this plan)
All registered virtual specialists. ✓ — activated for this case; ○ — not activated (available for other clinical scenarios).
Specialistskill_idVersionLast reviewedSign-offsDomain
Cellular therapy specialist (CAR-T)cellular_therapy_specialistv0.1.02026-04-250cellular_therapy
Clinical pharmacistclinical_pharmacistv0.1.02026-04-250clinical_pharmacy
Hematologist / oncohematologisthematologistv0.1.02026-04-250hematology_oncology
Hematopathologist (lymphoma / leukemia / myeloma)hematopathologistv0.1.02026-04-250hematopathology
Infectious disease / hepatologyinfectious_disease_hepatologyv0.1.02026-04-250infectious_diseases
Medical oncologist (solid-tumor chemotherapist)medical_oncologistv0.1.02026-04-250solid_oncology
Molecular geneticist / molecular oncologistmolecular_geneticistv0.1.02026-04-250molecular_oncology
Palliative carepalliative_carev0.1.02026-04-250palliative_care
Pathologist (general)pathologistv0.1.02026-04-250pathology
Primary care / family physicianprimary_carev0.1.02026-04-250primary_care
Psycho-oncologistpsychologistv0.1.02026-04-250psychosocial
Radiation oncologistradiation_oncologistv0.1.02026-04-250radiation_oncology
Radiologistradiologistv0.1.02026-04-250diagnostic_imaging
Social worker / case managersocial_worker_case_managerv0.1.02026-04-250psychosocial
Surgical oncologistsurgical_oncologistv0.1.02026-04-250surgical_oncology
Transplant specialist (BMT)transplant_specialistv0.1.02026-04-250cellular_therapy
plan_id: DPLAN-PZ-DIAG-MULTI-001-V1 | version: 1 | generated: 2026-05-12T18:41:26.945892+00:00
Per FDA non-device CDS positioning (CHARTER §15): Diagnostic-phase MDT support: structure the workup, identify the team, surface unresolved questions. Not a medical device; not a treatment plan.
Per FDA non-device CDS positioning (CHARTER §15): DIAGNOSTIC PHASE — this output describes diagnostic workup only. Treatment plan generation is blocked until histology is confirmed (CHARTER §15.2 C7). Do not treat on suspicion.
This document is an informational resource supporting tumor-board discussion (per CHARTER §11). It is not a system that makes clinical decisions. Every recommendation must be verified by the treating physician.