OpenOnco · Treatment Plan

Treatment plan — Mantle Cell Lymphoma

PLAN-BMA-TP53_MUT_MCL-V1 · v1 · 2026-08-17

Patient

BMA-TP53_MUT_MCL · Algorithm: ALGO-MCL-1L

DiagnosisMantle Cell Lymphoma

MOH / ICD-10C83.1

ICD-O-39673/3

Clinical significance of mutations (ESCAT)

Tumor-board context — the engine does not use these tiers to rank tracks

Biomarker	Variant	ESCAT	Evidence	Clinical significance	Drugs	Sources
ESCAT: clinical review pendingBIO-TP53-MUTATION	any pathogenic mutation OR del(17p)	IIA	Molecular evidence option SRC-CIVIC: Level A (Supports, Poor Outcome) SRC-CIVIC: Level B (Supports, N/A) Resistance or avoidance signal SRC-CIVIC: Level B ⚠ Resistance SRC-CIVIC: Level C ⚠ Resistance Trial or research option SRC-CIVIC: Level C (Supports, Sensitivity/Response) SRC-CIVIC: Level D (Supports, Sensitivity/Response)	TP53-mut MCL — predicts chemoimmuno failure. Acalabrutinib + rituximab (TRIANGLE / ECHO) preferred over R-CHOP/R-DHAP+autoSCT regardless of fitness.	acalabrutinib + rituximab (1L) ibrutinib + rituximab + venetoclax (R/R) CAR-T brexu-cel (R/R)	SRC-NCCN-BCELL-2025 SRC-ESMO-MCL-2024

Primary current-line option

Standard plan

★ DEFAULT

Indication

IND-MCL-1L-BTKI-R

Regimen

Acalabrutinib + Rituximab (continuous BTKi + R)

Drugs + NSZU

Acalabrutinib (DRUG-ACALABRUTINIB) 100 mg PO BID continuous · PO twice daily until progression or intolerance · PO ⚠ NSZU — not for this indication
Rituximab (DRUG-RITUXIMAB) 375 mg/m² · IV weekly × 4 (induction), then every 8 weeks × 2 years · IV ✓ NSZU covered

Hard contraindications

CI-HBV-NO-PROPHYLAXIS

Reason

Primary current-line option selected by ALGO-MCL-1L at step 3.

Other current-line alternatives (1 tracks)

Same treatment line; review when biomarker, access, contraindication, or patient-context assumptions change.

Aggressive plan

Indication

IND-MCL-1L-INTENSIVE

Regimen

Intensive 1L MCL: alternating R-CHOP / R-DHAP × 6 cycles + autoSCT consolidation + R maintenance

Drugs + NSZU

Induction — induction: 6 alternating cycles R-CHOP and R-DHAP (3 + 3); anti-CD20 with anthracycline-containing and HiDAC-containing blocks for maximum remission before autoSCT

Rituximab (DRUG-RITUXIMAB) 375 mg/m² · IV day 1 each cycle (R-CHOP + R-DHAP) · IV ✓ NSZU covered
Cyclophosphamide (DRUG-CYCLOPHOSPHAMIDE) 750 mg/m² · IV day 1 of R-CHOP cycles only · IV ⚠ NSZU — not for this indication
Doxorubicin (DRUG-DOXORUBICIN) 50 mg/m² · IV day 1 of R-CHOP cycles only · IV ✓ NSZU covered
Vincristine (DRUG-VINCRISTINE) 1.4 mg/m² (cap 2 mg) · IV day 1 of R-CHOP cycles only · IV ⚠ NSZU — not for this indication
Prednisone (DRUG-PREDNISONE) 100 mg · PO days 1-5 of R-CHOP cycles · PO ⚠ NSZU — not for this indication
Dexamethasone (DRUG-DEXAMETHASONE) 40 mg · IV days 1-4 of R-DHAP cycles only · IV ⚠ NSZU — not for this indication
Cytarabine (DRUG-CYTARABINE) 2 g/m² q12h · IV day 2 of R-DHAP cycles (HiDAC component) · IV ⚠ NSZU — not for this indication

Supportive care

SUP-PJP-PROPHYLAXIS, SUP-TLS-PROPHYLAXIS, SUP-ANTIEMETIC-PREMED

Hard contraindications

CI-HBV-NO-PROPHYLAXIS, CI-LVEF-LOW-FOR-ANTHRACYCLINE

Reason

Current-line alternative presented for HCP consideration

Pre-treatment investigations

Investigations before treatment start · critical / standard / desired · merged across tracks

ID	Name	Priority	Category	Where to order	Needed for
TEST-BM-ASPIRATE	Bone Marrow Aspirate	Critical	histology	—	aggressive
TEST-BM-TREPHINE	Bone Marrow Trephine	Critical	histology	—	aggressive
TEST-CBC	Complete Blood Count with Differential	Critical	lab	—	all tracks
TEST-CD20-IHC	CD20 Immunohistochemistry	Critical	histology	CSD Lab ✓ (code TBC)	all tracks
TEST-CMP	Comprehensive Metabolic Panel	Critical	lab	—	all tracks
TEST-FISH-PANEL	FISH (Fluorescence In Situ Hybridization)	Critical	genomic	CSD Lab ✓ (code TBC)	all tracks
TEST-HBV-SEROLOGY	Hepatitis B Serology Panel (HBsAg, anti-HBc total, anti-HBs)	Critical	lab	—	all tracks
TEST-HCV-ANTIBODY	HCV Antibody	Critical	lab	—	aggressive
TEST-HIV-SEROLOGY	HIV Antibody/Antigen	Critical	lab	—	all tracks
TEST-LDH	Lactate Dehydrogenase	Critical	lab	—	all tracks
TEST-LFT	Liver Function Tests (ALT, AST, bilirubin, ALP, GGT, albumin)	Critical	lab	—	all tracks
TEST-LN-EXCISIONAL-BIOPSY	Excisional LN Biopsy	Critical	histology	—	aggressive
TEST-PREGNANCY	Beta-HCG	Critical	lab	—	aggressive
TEST-B2-MICROGLOBULIN	Beta-2 Microglobulin	Standard	lab	—	aggressive
TEST-ECHO	Echocardiography	Standard	imaging	—	all tracks
TEST-PET-CT	FDG PET/CT (whole body)	Standard	imaging	—	all tracks
TEST-NGS-LYMPHOID-PANEL	Lymphoid NGS Panel	Desired	genomic	CSD Lab ✓ (code TBC)	all tracks

Red flags — PRO / CONTRA aggressive

PRO-AGGRESSIVE

Triggers that push toward the aggressive track

Mantle cell lymphoma with MIPI low risk (MIPI <5.7 / 0-3 simplified points) — supports standard intensified induction in fit younger patients (Nordic / R-DHAP-based) without further treatment escalation
MIPI (Hoster 2008) is the validated MCL prognostic index combining age, ECOG, LDH, WBC. MIPI low-risk has 5-yr OS ~80%; intermediate ~60%; high ~35%. In fit younger MCL, low-risk MIPI without TP53 / blastoid features supports the standard…
RF-MIPI-LOWSRC-NCCN-BCELL-2025SRC-ESMO-MCL-2024

CONTRA-AGGRESSIVE

Hard contraindications to escalation

Active or latent HBV without antiviral prophylaxis is an absolute contraindication to starting B-cell-depleting / immunomodulatory monoclonal antibody therapy (anti-CD20, anti-CD30 ADC, anti-CD38). Severe HBV reactivation hepatitis risk including fulminant hepatic failure.CI-HBV-NO-PROPHYLAXIS
Pre-treatment LVEF <50% is an absolute contraindication to anthracycline-containing regimens (R-CHOP, Pola-R-CHP, ABVD, BV-AVD, etc.). Cardiotoxicity from doxorubicin is dose-cumulative and often irreversible; starting with already-impaired function risks acute decompensation.CI-LVEF-LOW-FOR-ANTHRACYCLINE

What NOT to do

Explicit prohibitive rules, each grounded in a regimen / supportive care / contraindication entity

Standard plan (IND-MCL-1L-BTKI-R)

Do not skip TP53 / Ki67 — TP53-mutant requires consideration of CAR-T pathway and alloSCT consultation.
Do not prescribe without HBV screening + prophylaxis in HBsAg+ / anti-HBc+.
Do not combine with warfarin without strict monitoring.
Do not prescribe with concomitant strong CYP3A4 inhibitor — hold inhibitor or dose-modify acalabrutinib.

Aggressive plan (IND-MCL-1L-INTENSIVE)

Do not prescribe in TP53-mutant or blastoid MCL — chemoimmuno-resistant; direct route to BTKi-based (REG-ACALABRUTINIB-RITUXIMAB).
Do not skip baseline LVEF + cytogenetics + TP53 sequencing before start.
Do not use in age >65 OR ECOG >1 — toxicity overwhelms benefit; route to less intensive.
Do not skip HBV screening + entecavir prophylaxis.
Do not administer vincristine intrathecally — FATAL.

Monitoring schedule

Monitoring schedule by treatment phase

Standard plan · MON-CLL-BTKI

Phase	Window	Tests	Checkpoints
Baseline	Within 2 weeks before start	TEST-CBC, TEST-CMP, TEST-LFT, TEST-LDH, TEST-B2-MICROGLOBULIN, TEST-FISH-PANEL, TEST-NGS-LYMPHOID-PANEL, TEST-IMMUNOGLOBULINS, TEST-HBV-SEROLOGY, TEST-HCV-ANTIBODY, TEST-HIV-SEROLOGY, TEST-CECT-CAP, TEST-ECHO	Confirm CLL diagnosis: CD19+ CD5+ CD23+ flow on PB ≥5K monoclonal B-cells Risk stratification: del(17p), TP53, IGHV mutational status, karyotype iwCLL treatment indication documented (if asymptomatic — defer to surveillance) Cardiac baseline (atrial fibrillation history, hypertension control) HBV status + entecavir prophylaxis if HBsAg+ or anti-HBc+ (anti-CD20 in VenO regimen)
On treatment (BTKi)	Monthly × 3 months, then every 3 months	TEST-CBC, TEST-CMP, TEST-LFT	ALC trend (lymphocytosis early on BTKi is expected — not progression) Bleeding events; major bleed → hold BTKi AF symptoms → ECG; if AF → cardiology + anticoagulation strategy
On treatment (venetoclax)	Per CLL14 schedule during 12-month VenO course	TEST-CBC, TEST-CMP, TEST-LFT, TEST-URIC-ACID	TLS labs (K+, phosphate, calcium, uric acid, creatinine) per ramp-up schedule ANC + platelets pre each obinutuzumab dose Infusion reactions to obinutuzumab (especially first dose)
Response assessment	After cycle 6 (VenO) or every 6 months on BTKi	TEST-CBC, TEST-CECT-CAP, TEST-FLOW-CYTOMETRY	iwCLL response criteria (CR, PR, PR-L on BTKi, SD, PD) MRD assessment by flow on PB at end of VenO 12-month course
Follow-up	Every 3-6 months after treatment / continuously on BTKi	TEST-CBC, TEST-CMP, TEST-LFT	Surveillance for relapse (median PFS years for both regimens) Watch for Richter transformation (rapid LDH rise, new B-symptoms, isolated mass) — re-biopsy Second primary malignancy screening

Aggressive plan · MON-R-CHOP-REGIMEN

Phase	Window	Tests	Checkpoints
Baseline	Within 2 weeks before cycle 1	TEST-CBC, TEST-CMP, TEST-LFT, TEST-LDH, TEST-B2-MICROGLOBULIN, TEST-HBV-SEROLOGY, TEST-HCV-ANTIBODY, TEST-HIV-SEROLOGY, TEST-PET-CT, TEST-LN-EXCISIONAL-BIOPSY, TEST-FLOW-CYTOMETRY, TEST-CD20-IHC, TEST-ECHO, TEST-PREGNANCY, TEST-BM-ASPIRATE, TEST-BM-TREPHINE	Confirm CD20+ DLBCL histology; rule out double-hit (FISH for MYC/BCL2/BCL6) Confirm HBV status + entecavir prophylaxis plan if HBsAg+ or anti-HBc+ Baseline LVEF ≥50% before doxorubicin IPI calculation documented (age, ECOG, LDH, stage, extranodal sites) CNS-IPI calculation if anatomic risk sites or composite score concerning Fertility preservation discussion (sperm banking / oocyte cryo) for childbearing-age
On treatment	Day 1 of every 21-day cycle	TEST-CBC, TEST-CMP, TEST-LFT	ANC ≥1500 + platelets ≥100K before each cycle (delay or G-CSF if not) Neuropathy grade documented (CTCAE) — vincristine modification if ≥2 LVEF re-check after cumulative doxorubicin ~300 mg/m²
Interim response assessment	After cycles 2-4 (interim PET-CT)	TEST-PET-CT, TEST-LDH	Lugano response criteria + Deauville score If Deauville 4-5 with mass progression → consider salvage or trial
End of treatment	After cycle 6 (within 6-8 weeks)	TEST-PET-CT, TEST-CBC, TEST-CMP, TEST-LDH	Confirm CR vs PR vs SD vs PD by Lugano/Deauville Begin survivorship plan: cardiac surveillance schedule, vaccination catch-up, second-cancer screening
Follow-up (short-term)	Every 3 months × 2 years post-treatment	TEST-CBC, TEST-CMP, TEST-LFT, TEST-LDH	Surveillance for relapse (~40% relapse risk by 2 years overall) HBV reactivation monitoring continues for 12 months post anti-CD20
Follow-up (long-term)	Every 6 months years 3-5, then annually	TEST-CBC, TEST-LFT, TEST-ECHO	Late cardiomyopathy screening (LVEF) annually if cumulative dox >300 Annual second-malignancy screening (skin, breast, etc. age-appropriate)

Timeline

Treatment timeline — derived from regimen + monitoring schedule

Standard plan

Baseline

Within 2 weeks before start

Induction · Acalabrutinib + Rituximab (continuous BTKi + R)

28-day cycles × Acalabrutinib continuous; rituximab × 2 years then off

Response assessment

After cycle 6 (VenO) or every 6 months on BTKi

Follow-up

Every 3-6 months after treatment / continuously on BTKi

Aggressive plan

Baseline

Within 2 weeks before cycle 1

Induction · Intensive 1L MCL: alternating R-CHOP / R-DHAP × 6 cycles + autoSCT consolidation + R maintenance

21-day cycles × 6 alternating (3 R-CHOP + 3 R-DHAP), then BEAM/CBV-conditioned autoSCT, then R maintenance every 2 mo × 3 years

Response assessment

After cycles 2-4 (interim PET-CT)

Follow-up

Every 3 months × 2 years post-treatment

MDT brief

Discussion questions (8, 6 blocking)

BLOCKING OQ-CD20-CONFIRMATION
Is CD20+ status confirmed by histology (IHC)? Without CD20+, rituximab/obinutuzumab are not indicated.
Anti-CD20 therapy is the backbone of most lines of treatment; absence of CD20 expression fully changes the regimen.
→ pathologist
OQ-STAGING-COMPLETE
Has complete staging been done (Lugano + PET/CT or CT)?
Prognosis and track selection depend on stage and tumor burden.
→ radiologist
OQ-LDH-CURRENT
What is the current LDH? Marker of tumor burden and transformation.
LDH is part of the prognostic indices of indolent lymphomas.
→ hematologist
BLOCKING OQ-BIOMARKER-CCND1-IHC
What is the status of Cyclin D1 expression by IHC (encoded by CCND1) (BIO-CCND1-IHC)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive (cyclin D1 nuclear staining) — diagnostic hallmark of MCL.
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
BLOCKING OQ-BIOMARKER-CD20-IHC
What is the status of CD20 expression by immunohistochemistry (BIO-CD20-IHC)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive.
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
BLOCKING OQ-BIOMARKER-CD5-IHC
What is the status of CD5 expression by IHC / flow cytometry (BIO-CD5-IHC)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive (CD5+) — part of MCL immunophenotype panel; CD5-negative MCL is rare but recognised.
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ pathologist
BLOCKING OQ-BIOMARKER-MCL-MIPI
What is the status of Mantle Cell Lymphoma International Prognostic Index (MIPI) (BIO-MCL-MIPI)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: MIPI 0-11 (low/intermediate/high) — required risk stratifier; informs intensity choice and surveillance.
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ medical_oncologist
BLOCKING OQ-BIOMARKER-T11-14-IGH-CCND1
What is the status of t(11;14)(q13;q32) IGH/CCND1 by FISH (BIO-T11-14-IGH-CCND1)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive by FISH — diagnostic; required when CCND1-IHC equivocal or to confirm classical MCL.
A treatment-track biomarker requirement is missing from the patient profile; the MDT should verify the test result, method, specimen, and date before relying on this option.
→ molecular_geneticist

MDT talk tree (9 steps)

#	Owner	Topic	Action
1	medical_oncologist	Biomarker status BLOCKING	What is the status of Mantle Cell Lymphoma International Prognostic Index (MIPI) (BIO-MCL-MIPI)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: MIPI 0-11 (low/intermediate/high) — required risk stratifier; informs intensity choice and surveillance.
2	molecular_geneticist	Biomarker status BLOCKING	What is the status of t(11;14)(q13;q32) IGH/CCND1 by FISH (BIO-T11-14-IGH-CCND1)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive by FISH — diagnostic; required when CCND1-IHC equivocal or to confirm classical MCL.
3	pathologist	Biomarker status BLOCKING	What is the status of Cyclin D1 expression by IHC (encoded by CCND1) (BIO-CCND1-IHC)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive (cyclin D1 nuclear staining) — diagnostic hallmark of MCL.
4	pathologist	Biomarker status BLOCKING	What is the status of CD20 expression by immunohistochemistry (BIO-CD20-IHC)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive.
5	pathologist	Biomarker status BLOCKING	What is the status of CD5 expression by IHC / flow cytometry (BIO-CD5-IHC)? It is required by track(s): IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE. Expected value: positive (CD5+) — part of MCL immunophenotype panel; CD5-negative MCL is rare but recognised.
6	pathologist	Pathology confirmation BLOCKING	Is CD20+ status confirmed by histology (IHC)? Without CD20+, rituximab/obinutuzumab are not indicated.
7	hematologist	Staging / disease burden	What is the current LDH? Marker of tumor burden and transformation.
8	radiologist	Staging / disease burden	Has complete staging been done (Lugano + PET/CT or CT)?
9	clinical_pharmacist	Specialist review	Chemoimmunotherapy regimen — drug-drug interactions, dose adjustments, premedication.

Skills (required) — mandatory virtual specialists (1)

Hematologist / oncohematologist required
Lymphoma diagnosis — leading specialty for treatment management.
Owns: OQ-LDH-CURRENT

Skills (recommended) — for consideration (3)

Clinical pharmacist recommended
Chemoimmunotherapy regimen — drug-drug interactions, dose adjustments, premedication.
Molecular geneticist / molecular oncologist recommended
Indication references an actionable genomic biomarker — mutation / target / actionability interpretation needed.
Owns: OQ-BIOMARKER-T11-14-IGH-CCND1
Pathologist (general) recommended
Confirm lymphoma histology + assess transformation risk (DLBCL/Richter).
Owns: OQ-CD20-CONFIRMATION, OQ-BIOMARKER-CCND1-IHC, OQ-BIOMARKER-CD20-IHC, OQ-BIOMARKER-CD5-IHC

Data quality

Incomplete for default-track review. Default-track review is incomplete until required biomarker gaps are resolved.

Biomarker coverage: 0/5 known (0%), 5 missing, 5 default-track gaps
Missing critical: cd20_ihc_status, lugano_stage
Missing recommended: ldh_ratio_to_uln, fib4_index, pet_ct_date
Unevaluated RedFlags: RF-MCL-BLASTOID-OR-TP53, RF-MCL-BLASTOID-VARIANT, RF-MCL-FRAILTY-AGE, RF-MCL-INFECTION-SCREENING, RF-MCL-ORGAN-DYSFUNCTION, RF-MCL-POST-BTKI-C481-ACTIONABLE, RF-MCL-TRANSFORMATION-PROGRESSION, RF-MIPI-HIGH, RF-MIPI-LOW

Missing data for doctor action

Priority	Clinical item	Owner	Why it matters	Next action	Blocks
CRITICAL	CD20 IHC status `cd20_ihc_status`	pathologist	Confirms CD20-directed therapy is biologically appropriate.	Verify CD20 IHC result, specimen, method, and report date.	-
CRITICAL	Lugano stage `lugano_stage`	radiologist	Defines lymphoma extent and supports tumor-burden and response-assessment decisions.	Document Lugano stage from PET/CT or contrast CT staging.	-
RECOMMENDED	LDH ratio to ULN `ldh_ratio_to_uln`	medical_oncologist	Supports prognostic scoring and aggressive-biology flags.	Enter LDH with local upper limit of normal.	-
RECOMMENDED	FIB-4 liver fibrosis index `fib4_index`	infectious_disease_hepatology	Screens hepatic fibrosis risk before hepatotoxic therapy or antiviral coordination.	Calculate FIB-4 from age, AST, ALT, and platelet count.	-
RECOMMENDED	PET/CT date `pet_ct_date`	radiologist	Shows whether baseline staging is recent enough for treatment planning and later response comparison.	Document baseline PET/CT date or explain alternative staging modality.	-

Missing biomarker	Label	MDT owner	Default track	Required by	Next action
`BIO-CCND1-IHC`	Cyclin D1 expression by IHC (encoded by CCND1)	pathologist	yes	IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE	Verify result, method, specimen, and report date before sign-off. Expected/constraint: positive (cyclin D1 nuclear staining) — diagnostic hallmark of MCL
`BIO-CD20-IHC`	CD20 expression by immunohistochemistry	pathologist	yes	IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE	Verify result, method, specimen, and report date before sign-off. Expected/constraint: positive
`BIO-CD5-IHC`	CD5 expression by IHC / flow cytometry	pathologist	yes	IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE	Verify result, method, specimen, and report date before sign-off. Expected/constraint: positive (CD5+) — part of MCL immunophenotype panel; CD5-negative MCL is rare but recognised
`BIO-MCL-MIPI`	Mantle Cell Lymphoma International Prognostic Index (MIPI)	medical_oncologist	yes	IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE	Verify result, method, specimen, and report date before sign-off. Expected/constraint: MIPI 0-11 (low/intermediate/high) — required risk stratifier; informs intensity choice and surveillance
`BIO-T11-14-IGH-CCND1`	t(11;14)(q13;q32) IGH/CCND1 by FISH	molecular_geneticist	yes	IND-MCL-1L-BTKI-R, IND-MCL-1L-INTENSIVE	Verify result, method, specimen, and report date before sign-off. Expected/constraint: positive by FISH — diagnostic; required when CCND1-IHC equivocal or to confirm classical MCL

Technical MDT skill metadata (4/16 activated in this plan)

All registered virtual specialists. ✓ — activated for this case; ○ — not activated (available for other clinical scenarios).

Specialist	skill_id	Version	Last reviewed	Domain
Cellular therapy specialist (CAR-T)	`cellular_therapy_specialist`	v0.1.0	2026-04-25	cellular_therapy
Clinical pharmacist	`clinical_pharmacist`	v0.1.0	2026-04-25	clinical_pharmacy
Hematologist / oncohematologist	`hematologist`	v0.1.0	2026-04-25	hematology_oncology
Hematopathologist (lymphoma / leukemia / myeloma)	`hematopathologist`	v0.1.0	2026-04-25	hematopathology
Infectious disease / hepatology	`infectious_disease_hepatology`	v0.1.0	2026-04-25	infectious_diseases
Medical oncologist (solid-tumor chemotherapist)	`medical_oncologist`	v0.1.0	2026-04-25	solid_oncology
Molecular geneticist / molecular oncologist	`molecular_geneticist`	v0.1.0	2026-04-25	molecular_oncology
Palliative care	`palliative_care`	v0.1.0	2026-04-25	palliative_care
Pathologist (general)	`pathologist`	v0.1.0	2026-04-25	pathology
Primary care / family physician	`primary_care`	v0.1.0	2026-04-25	primary_care
Psycho-oncologist	`psychologist`	v0.1.0	2026-04-25	psychosocial
Radiation oncologist	`radiation_oncologist`	v0.1.0	2026-04-25	radiation_oncology
Radiologist	`radiologist`	v0.1.0	2026-04-25	diagnostic_imaging
Social worker / case manager	`social_worker_case_manager`	v0.1.0	2026-04-25	psychosocial
Surgical oncologist	`surgical_oncologist`	v0.1.0	2026-04-25	surgical_oncology
Transplant specialist (BMT)	`transplant_specialist`	v0.1.0	2026-04-25	cellular_therapy

Sources cited

SRC-ESMO-LYMPHOMA-2025: Lymphomas: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up (2025)
SRC-NCCN-BCELL-2025: NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas (v.2.2025)

Experimental options (clinical trials)

Third plan track — open-enrollment trials from ClinicalTrials.gov. Render-time metadata; engine selection is not affected by this block (CHARTER §8.3). Last synced: 2026-08-17.

NCT	Title	Phase	Status	Sponsor	UA	Signals
NCT05544019	Study of SGR-1505 in Mature B-Cell Neoplasms	PHASE1	RECRUITING	Schrödinger, Inc.	UA Kyiv — ARENSIA Research Clinic at Harmony Health Clinic (RECRUITING)	Phase 1 only
NCT06022029	A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.	PHASE1	RECRUITING	OncoNano Medicine, Inc.	—	Phase 1 only
NCT07377578	A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma	PHASE3	RECRUITING	Guangzhou Lupeng Pharmaceutical Company LTD.	—	Surrogate endpoint only Single country
NCT06564038	A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies	PHASE1 / PHASE2	RECRUITING	AstraZeneca	—	—
NCT03676504	Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR	PHASE1 / PHASE2	RECRUITING	University Hospital Heidelberg	—	Single country
NCT06151730	Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study	N/A	RECRUITING	Mayo Clinic	—	Single country
NCT04368702	CONFIRM: Magnetic Resonance Guided Radiation Therapy	NA	RECRUITING	Brigham and Women's Hospital	—	Single country
NCT06846489	Acalabrutinib Plus Rituximab for the Treatment of Elderly or Low- to Intermediate-Risk Younger Untreated Mantle Cell Lymphoma	PHASE2	RECRUITING	Sun Yat-sen University	—	Single country
NCT07261163	Obinutuzumab, Zanubrutinib, and Lenalidomide in First-line Treatment of Mantle Cell Lymphoma	PHASE2	RECRUITING	Institute of Hematology & Blood Diseases Hospital, China	—	Small N (<50) Surrogate endpoint only Single country
NCT07341191	Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma Planned for Standard of Care CAR-T Cell Therapy	PHASE2	RECRUITING	Canadian Cancer Trials Group	—	Small N (<50) Single country

Verify recruitment status directly with the trial site. ctgov data can lag behind current UA-site status.

Option availability in Ukraine

Per-track UA registration · NSZU · cost · access pathway. Render-time metadata; engine selection does not depend on these fields (CHARTER §8.3).

Option	UA registration	NSZU	Cost orientation	Access pathway
Standard plan Acalabrutinib + Rituximab (continuous BTKi + R) (REG-ACALABRUTINIB-RITUXIMAB)	✓ registered	✓ covered	₴-? — verify pathway	NSZU formulary
Aggressive plan Intensive 1L MCL: alternating R-CHOP / R-DHAP × 6 cycles + autoSCT consolidation + R maintenance (REG-MCL-INTENSIVE-RDHAP-AUTOSCT)	✓ registered	✓ covered	₴-? — verify pathway	NSZU formulary
Trial · NCT05544019 Study of SGR-1505 in Mature B-Cell Neoplasms UA site available — verify enrollment status with site	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT06022029 A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas. No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07377578 A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT06564038 A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT03676504 Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT06151730 Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT04368702 CONFIRM: Magnetic Resonance Guided Radiation Therapy No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT06846489 Acalabrutinib Plus Rituximab for the Treatment of Elderly or Low- to Intermediate-Risk Younger Untreated Mantle Cell Lymphoma No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07261163 Obinutuzumab, Zanubrutinib, and Lenalidomide in First-line Treatment of Mantle Cell Lymphoma No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor
Trial · NCT07341191 Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma Planned for Standard of Care CAR-T Cell Therapy No UA site listed — international referral required	— unknown	— unknown	self-pay: ₴0/course	Trial sponsor

Cost information is orientation. Verify with a specific pharmacy / foundation / trial site. Status updated: 2026-08-17.

plan_id: PLAN-BMA-TP53_MUT_MCL-V1 | version: 1 | generated: 2026-08-17T08:06:32.152725+00:00

Per FDA non-device CDS positioning (CHARTER §15): Outpatient oncology treatment planning to support tumor-board discussion. Not a medical device; not for autonomous clinical decision-making.

Per FDA non-device CDS positioning (CHARTER §15): Both treatment options below are presented for review. The engine's selection of a 'recommended' default does not constitute a clinical decision. Final treatment selection requires HCP judgment incorporating information not available to the system.

This document is an informational resource supporting tumor-board discussion (per CHARTER §11). It is not a system that makes clinical decisions. Every recommendation must be verified by the treating physician.