Low adherence to a Mediterranean dietary pattern (Trichopoulou Mediterranean Diet Score [...

Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.

ID	`RF-LIFESTYLE-LOW-MEDITERRANEAN-DIET-PREVENTION`
Тип	Тривожна ознака
Статус	переглянуто 2026-05-18 \| очікує клінічного підпису
Хвороби	`DIS-CRC`
Джерела	`SRC-NCCN-BCELL-2025` `SRC-NCCN-COLON-2025`

Походження тривожної ознаки

Визначення	Low adherence to a Mediterranean dietary pattern (Trichopoulou Mediterranean Diet Score [MDS] 0-3 of 9, or PREDIMED-style score in the lowest tertile, or 14-item MEDAS <7). Mediterranean dietary pattern = high intake of olive oil, vegetables, fruits, whole grains, legumes, nuts, fish; moderate dairy + wine with meals; low intake of red/processed meat + sweets. EPIC + Nurses' Health Study + PREDIMED cohorts: high adherence associated with ~12-15% reduction in overall cancer incidence + mortality; strongest signals for CRC, breast, gastric, hepatocellular cancers + dietary-pattern co-benefits for cardiovascular disease (PREDIMED 2013 RCT primary endpoint). Mechanisms: high polyphenol (olive oil, vegetables) + ω-3 fatty acid (fish) + fibre + antioxidant content; low pro-inflammatory red/ processed meat + refined-carbohydrate content; favorable microbiome modulation. Prevention-persona RedF...
Клінічний напрям	investigate
Категорія	other

Логіка спрацьовування

{
  "any_of": [
    {
      "finding": "mediterranean_diet_score_lt_4",
      "value": true
    },
    {
      "finding": "medas_score_lt_7",
      "value": true
    },
    {
      "finding": "predimed_lowest_tertile",
      "value": true
    }
  ],
  "type": "lab_value"
}

Нотатки

Prevention-persona RedFlag for low Mediterranean-diet adherence. Population-level dietary-pattern lever — distinct from single-nutrient RFs (fibre, calcium, red meat). PREDIMED RCT (2013 primary endpoint cardiovascular; 2015 secondary CRC analysis) + EPIC + NHS observational signal. Anchored to DIS-CRC because pattern-cancer evidence is strongest there; multi-cancer benefit framed in rationale. Engine routes to PreventionPlan recommending dietary-pattern counseling + USPSTF-cadence screening per anchor. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode.

Де використовується

Indications

IND-LIFESTYLE-LOW-MEDITERRANEAN-DIET-PREVENTION-ADOPTION - IND-LIFESTYLE-LOW-MEDITERRANEAN-DIET-PREVENTION-ADOPTION
IND-LIFESTYLE-LOW-MEDITERRANEAN-DIET-PREVENTION-OBSERVATION - IND-LIFESTYLE-LOW-MEDITERRANEAN-DIET-PREVENTION-OBSERVATION