Regular consumption of maté (Ilex paraguariensis infusion) prepared and drunk at very hig...

Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.

ID	`RF-LIFESTYLE-HOT-MATE-ESOPHAGEAL-PREVENTION`
Тип	Тривожна ознака
Статус	переглянуто 2026-05-19 \| очікує клінічного підпису
Хвороби	`DIS-ESOPHAGEAL`
Джерела	`SRC-NCCN-BCELL-2025` `SRC-NCCN-ESOPHAGEAL-2025`

Походження тривожної ознаки

Визначення	Regular consumption of maté (Ilex paraguariensis infusion) prepared and drunk at very high temperatures (≥65°C / ≥149°F) — characteristic of traditional gourd-and-bombilla preparation in southern South America (Argentina, Brazil, Paraguay, Uruguay, southern Chile) and diaspora communities. IARC Monograph 116 (2016) classified drinking very hot beverages above 65°C as Group 2A (probably carcinogenic) — limited evidence in humans (consistent associations with esophageal squamous cell carcinoma in maté-drinking, hot-tea, and hot-coffee cohorts, with residual confounding from tobacco / alcohol co-exposure not fully excluded), sufficient evidence in experimental animals (thermal injury → chronic inflammation → field carcinogenesis in rodent esophagus models). Important: at temperatures <60°C, no association is observed; maté per se (the herb / its phytochemicals) is NOT classified as carcino...
Клінічний напрям	investigate
Категорія	other

Логіка спрацьовування

{
  "any_of": [
    {
      "finding": "very_hot_mate_consumption_ge_65c",
      "value": true
    },
    {
      "finding": "traditional_mate_culture_high_temperature_regular",
      "value": true
    }
  ],
  "type": "lab_value"
}

Нотатки

Prevention-persona RedFlag — v0.3 IARC 2A probable-carcinogen batch (2026-05-19). IARC Group 2A probable — limited human evidence; clinical recommendation more conservative than Group 1. IARC Monograph 116 (2016) is the canonical evidence anchor and is NOT yet a separate SRC entity in KB; cited in notes only. Coexistence with RF-LIFESTYLE-HOT-BEVERAGES-PREVENTION (predecessor generic-hot-beverages RF covering teas / coffees / water at ≥65°C across all regional traditions) is deliberate. This new RF is the maté-specific narrowing — fires on the highly characteristic gourd- and-bombilla preparation pattern with documented southern-South- American epidemiology, lets the engine surface culturally-tuned counseling (target audience: diaspora communities, immigrants from Argentina/Brazil/Paraguay/Uruguay/southern Chile). Both RFs may fire on the same patient when both thresholds are met; engine treats them as additive. Crucial framing point: the carcinogen is thermal injury, NOT maté per se. Counseling targets temperature (cool to <60°C / wait several minutes before drinking) NOT cessation of maté consumption. STUB pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode exemption.

Де використовується

Indications

IND-LIFESTYLE-HOT-MATE-ESOPHAGEAL-PREVENTION-INTENSIFIED-SURVEILLANCE - IND-LIFESTYLE-HOT-MATE-ESOPHAGEAL-PREVENTION-INTENSIFIED-SURVEILLANCE
IND-LIFESTYLE-HOT-MATE-ESOPHAGEAL-PREVENTION-OBSERVATION - IND-LIFESTYLE-HOT-MATE-ESOPHAGEAL-PREVENTION-OBSERVATION