HIV infection (positive serology) in an individual without a current AIDS-defining or HIV...
Детермінований перегляд YAML-сутності з джерельної бази. Клінічний авторитет лишається за вказаними source ID та статусом клінічного sign-off.
| ID | RF-CHRONIC-HIV-MALIGNANCY-PREVENTION |
|---|---|
| Тип | Тривожна ознака |
| Статус | переглянуто 2026-05-18 | очікує клінічного підпису |
| Хвороби | DIS-DLBCL-NOS |
| Джерела | SRC-NCCN-BCELL-2025 SRC-NIH-AIDS-2024 |
Походження тривожної ознаки
| Визначення | HIV infection (positive serology) in an individual without a current AIDS-defining or HIV-associated malignancy diagnosis. IARC Group 1 carcinogen (HIV-1) — drives elevated risk of Kaposi sarcoma (KS), non-Hodgkin lymphoma (especially DLBCL, Burkitt, PCNSL), invasive cervical cancer (AIDS-defining trio), and elevated incidence of Hodgkin lymphoma, anal cancer, HCC (via HCV co-infection), and oropharyngeal cancer. Effective antiretroviral therapy (ART) with durable virological suppression substantially reduces all AIDS-defining malignancy incidence and modestly reduces non-AIDS-defining cancer incidence. Prevention-persona RedFlag (§20 ratification 2026-05-18). |
|---|---|
| Клінічний напрям | investigate |
| Категорія | other |
Логіка спрацьовування
{
"any_of": [
{
"finding": "hiv_status",
"value": "positive"
},
{
"finding": "hiv_serology",
"value": "positive"
}
],
"type": "lab_value"
}
Нотатки
Prevention-persona RedFlag for HIV-associated cancer prevention. Fires on positive HIV serology in patient without AIDS-defining or HIV-associated malignancy. Engine routes to PreventionPlan recommending durable ART suppression (per IND-CHRONIC-HIV-PREVENTION-ART) + cancer screening cadence (annual anal cytology in MSM/HIV+; q3-yearly cervical Pap in WLHIV; opportunistic Kaposi/oral hairy leukoplakia visual screening). STUB pending Co-Lead review. Cancer scope: anchored to DIS-DLBCL-NOS as the canonical HIV-associated NHL. KS, cervical, anal, Hodgkin, HCC are also HIV-associated; covered via screening recommendations in the ART indication rationale rather than discrete Disease anchors (until DIS-KAPOSI etc. land in v0.2-A authoring backlog).
Де використовується
Indications
IND-CHRONIC-HIV-PREVENTION-ART- IND-CHRONIC-HIV-PREVENTION-ARTIND-CHRONIC-HIV-PREVENTION-OBSERVATION- IND-CHRONIC-HIV-PREVENTION-OBSERVATIONIND-UNIVERSAL-IMMUNOCOMPROMISED-PREVENTION-STRATIFIED-SCREENING- IND-UNIVERSAL-IMMUNOCOMPROMISED-PREVENTION-STRATIFIED-SCREENING
Тривожна ознака
RF-CHRONIC-HHV8-MALIGNANCY-PREVENTION- HHV-8 (Kaposi sarcoma-associated herpesvirus, KSHV) seropositivity in an immunocompromise...RF-CHRONIC-HIV-HBV-COINFECTION-PREVENTION- Concurrent HIV + HBV coinfection (HIV-positive AND HBsAg positive ≥6 months OR HBV-DNA de...RF-UNIVERSAL-IMMUNOCOMPROMISED-CANCER-RISK- Chronic immunosuppression ≥1 year — any of: (a) untreated or treated HIV with CD4 nadir <...