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HIV infection (positive serology) in an individual without a current AIDS-defining or HIV...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-CHRONIC-HIV-MALIGNANCY-PREVENTION
TypeRed flag
Statusreviewed 2026-05-18 | pending_clinical_signoff
DiseasesDIS-DLBCL-NOS
SourcesSRC-NCCN-BCELL-2025 SRC-NIH-AIDS-2024

Red Flag Origin

DefinitionHIV infection (positive serology) in an individual without a current AIDS-defining or HIV-associated malignancy diagnosis. IARC Group 1 carcinogen (HIV-1) — drives elevated risk of Kaposi sarcoma (KS), non-Hodgkin lymphoma (especially DLBCL, Burkitt, PCNSL), invasive cervical cancer (AIDS-defining trio), and elevated incidence of Hodgkin lymphoma, anal cancer, HCC (via HCV co-infection), and oropharyngeal cancer. Effective antiretroviral therapy (ART) with durable virological suppression substantially reduces all AIDS-defining malignancy incidence and modestly reduces non-AIDS-defining cancer incidence. Prevention-persona RedFlag (§20 ratification 2026-05-18).
Clinical directioninvestigate
Categoryother

Trigger Logic

{
  "any_of": [
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "hiv_serology",
      "value": "positive"
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for HIV-associated cancer prevention. Fires on positive HIV serology in patient without AIDS-defining or HIV-associated malignancy. Engine routes to PreventionPlan recommending durable ART suppression (per IND-CHRONIC-HIV-PREVENTION-ART) + cancer screening cadence (annual anal cytology in MSM/HIV+; q3-yearly cervical Pap in WLHIV; opportunistic Kaposi/oral hairy leukoplakia visual screening). STUB pending Co-Lead review. Cancer scope: anchored to DIS-DLBCL-NOS as the canonical HIV-associated NHL. KS, cervical, anal, Hodgkin, HCC are also HIV-associated; covered via screening recommendations in the ART indication rationale rather than discrete Disease anchors (until DIS-KAPOSI etc. land in v0.2-A authoring backlog).

Used By

Indications

Red flag