Family pedigree suggestive of SDH (succinate dehydrogenase) deficiency syndrome — confirm...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-SDH-FAMILY-HISTORY-SUSPICION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-PHEOCHROMOCYTOMA` `DIS-RCC`
Sources	`SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Family pedigree suggestive of SDH (succinate dehydrogenase) deficiency syndrome — confirmed germline SDHB / SDHC / SDHD / SDHA / SDHAF2 pathogenic variant OR cluster of paraganglioma + pheochromocytoma + renal cell carcinoma + GIST (Carney-Stratakis). SDH-deficient RCC is aggressive (often type-2-papillary morphology). Prevention-persona RedFlag (§20 v0.2-B).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "family_sdh_known_pathogenic_variant",
      "value": true
    },
    {
      "finding": "family_paraganglioma_or_pheochromocytoma_pediatric_or_familial",
      "value": true
    },
    {
      "finding": "family_sdh_deficient_rcc_or_gist",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for SDH-deficiency syndrome. STUB pending two-Co-Lead signoff.

Used By

Indications

IND-SDH-SUSPICION-PREVENTION-ENHANCED-SURVEILLANCE - IND-SDH-SUSPICION-PREVENTION-ENHANCED-SURVEILLANCE
IND-SDH-SUSPICION-PREVENTION-GENETIC-COUNSELING - IND-SDH-SUSPICION-PREVENTION-GENETIC-COUNSELING

Red flag

RF-SDH-CONFIRMED-CARRIER - Confirmed germline pathogenic / likely-pathogenic variant in one of the SDHx genes — SDHB...