Low-grade glioma with raised intracranial pressure or refractory seizures requiring emerg...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-GLIOMA-LOW-GRADE-INTRACRANIAL-PRESSURE`
Type	Red flag
Status	reviewed 2026-04-27 \| pending_clinical_signoff
Diseases	`DIS-GLIOMA-LOW-GRADE`
Sources	`SRC-EANO-GBM-2024` `SRC-NCCN-CNS-2025`

Red Flag Origin

Definition	Low-grade glioma with raised intracranial pressure or refractory seizures requiring emergency intervention: midline shift ≥5 mm, papilledema, GCS drop, status epilepticus or breakthrough seizures despite ≥2 AEDs
Clinical direction	hold
Category	organ-dysfunction
Shifts algorithm	ALGO-GLIOMA-LGG-1L

Trigger Logic

{
  "any_of": [
    {
      "finding": "raised_intracranial_pressure",
      "value": true
    },
    {
      "comparator": ">=",
      "finding": "midline_shift_mm",
      "threshold": 5
    },
    {
      "finding": "status_epilepticus",
      "value": true
    },
    {
      "finding": "refractory_seizures_on_2_aeds",
      "value": true
    },
    {
      "comparator": "<",
      "finding": "gcs_score",
      "threshold": 12
    }
  ],
  "type": "composite"
}

Notes

Per NCCN-CNS + EANO 2024: dexamethasone 4-16 mg/day for vasogenic edema; urgent neurosurgical evaluation for resection (max safe resection improves OS in LGG); levetiracetam preferred AED (no P450 induction → preserves chemo efficacy); status epilepticus treated per neurology emergency protocol. Direction HOLD on systemic / RT therapy until ICP managed and resection assessed. Priority 8. STUB — requires clinical co-lead signoff.

Used By

Indications

IND-GLIOMA-LOW-GRADE-1L-RT-PCV - IND-GLIOMA-LOW-GRADE-1L-RT-PCV