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Follicular lymphoma meeting any GELF criterion — high tumor burden warranting systemic th...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "finding": "fl_gelf_high_burden",
      "value": true
    },
    {
      "comparator": ">=",
      "finding": "dominant_nodal_mass_cm",
      "threshold": 7.0
    },
    {
      "finding": "b_symptoms_present",
      "value": true
    },
    {
      "finding": "splenomegaly_below_umbilicus",
      "value": true
    },
    {
      "finding": "ldh_above_uln",
      "value": true
    },
    {
      "finding": "rapid_progression",
      "value": true
    },
    {
      "finding": "compressive_symptoms",
      "value": true
    },
    {
      "finding": "cytopenia_due_to_lymphoma",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

GELF (Brice 1997) criteria are the long-standing trigger for active treatment in advanced-stage FL. Any single criterion qualifies: nodal/extranodal mass ≥7 cm, ≥3 nodal sites each ≥3 cm, B-symptoms, splenomegaly past umbilicus, pleural/peritoneal effusion, leukemic phase, cytopenia (Hb<10 / plt<100K / ANC<1.5K) attributable to lymphoma, compressive symptoms. Companion to RF-FL-HIGH-TUMOR-BURDEN-GELF (existing) — this RF carries a clearer ID for cross-disease reuse and the cohort label needed by the FL-1L decision tree. Without GELF criteria, observation is standard (RF-GELF-LOW-BURDEN).

Used By

Algorithms

• ALGO-FL-1L - ALGO-FL-1L