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Active or latent infection requiring resolution / prophylaxis before initiating R-CHOP-cl...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "anti_hbc_total",
      "value": "positive"
    },
    {
      "finding": "hiv_status",
      "value": "positive"
    },
    {
      "finding": "active_tb",
      "value": true
    }
  ],
  "type": "lab_value"
}

Notes

HBsAg+ → mandatory entecavir or tenofovir prophylaxis from –7d through +12mo post-last-anti-CD20 (NCCN B-Cell §HBV-1; ESMO DLBCL §pre-treatment). HIV+ DLBCL is treatable with R-CHOP or DA-EPOCH-R but requires concomitant ART — use the existing IND-DLBCL-1L-RCHOP, but the clinical team must confirm ART regimen and CD4 baseline first. Active TB: full anti-TB course before chemoimmunotherapy when feasible. This RF surfaces the hold; the algorithm engages ALGO-DLBCL-1L step 1 to defer indication selection until prophylaxis/ART/anti-TB pathway is documented.

Used By

Algorithms

• ALGO-DLBCL-1L - ALGO-DLBCL-1L

Indications

• IND-DLBCL-2L-LISOCEL - IND-DLBCL-2L-LISOCEL
• IND-DLBCL-3L-EPCORITAMAB - IND-DLBCL-3L-EPCORITAMAB
• IND-DLBCL-3L-GLOFITAMAB - IND-DLBCL-3L-GLOFITAMAB