Persistent high-risk HPV infection (HPV-16, 18, 31, 33, 45, 52, 58 detected on cervical c...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-CHRONIC-HPV-MALIGNANCY-PREVENTION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-ANAL-SCC` `DIS-CERVICAL`
Sources	`SRC-NCCN-ANAL-2025` `SRC-NCCN-CERVICAL-2025`

Red Flag Origin

Definition	Persistent high-risk HPV infection (HPV-16, 18, 31, 33, 45, 52, 58 detected on cervical co-test, anal cytology, or oropharyngeal swab), or absence of completed HPV vaccination series in age-eligible individual. IARC Group 1 carcinogen (HPV) — established etiological driver of cervical (>99% attributable), anal (~90%), oropharyngeal (~70% in US/EU), vulvar/vaginal, and penile squamous cell carcinomas. HPV vaccination (Gardasil-9 nonavalent) reduces incidence; screening (cervical Pap/HPV co-testing, anal cytology in high-risk groups) enables early-stage detection. Prevention-persona RedFlag (§20 ratification 2026-05-18).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "hpv_high_risk_status",
      "value": "positive"
    },
    {
      "finding": "hpv_vaccine_status",
      "value": "incomplete"
    },
    {
      "finding": "hpv_vaccine_status",
      "value": "unvaccinated"
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for HPV-associated cancer prevention. Fires on persistent high-risk HPV positivity OR incomplete/absent vaccination in age-eligible individual. Engine routes to PreventionPlan recommending vaccination (Gardasil-9) and/or risk-group-appropriate screening cadence (cervical: USPSTF Pap+HPV co-test q5y ages 30-65; anal: HRA + cytology q1y in MSM/HIV+/post-transplant). STUB pending Co-Lead review. Cancer scope: anchored to DIS-CERVICAL and DIS-ANAL-SCC. Oropharyngeal squamous cell carcinoma and vulvar/vaginal/penile not yet in KB — v0.2-A authoring backlog.

Used By

Indications

IND-CHRONIC-HPV-PREVENTION-OBSERVATION - IND-CHRONIC-HPV-PREVENTION-OBSERVATION
IND-CHRONIC-HPV-PREVENTION-VACCINATION-SCREENING - IND-CHRONIC-HPV-PREVENTION-VACCINATION-SCREENING