Family pedigree suggestive of BAP1 tumor predisposition syndrome — confirmed germline BAP...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-BAP1-FAMILY-HISTORY-SUSPICION`
Type	Red flag
Status	reviewed 2026-05-18 \| pending_clinical_signoff
Diseases	`DIS-MESOTHELIOMA` `DIS-RCC`
Sources	`SRC-ASCO-ACMG-LYNCH-2014` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Family pedigree suggestive of BAP1 tumor predisposition syndrome — confirmed germline BAP1 pathogenic variant in family OR cluster of characteristic BAP1-spectrum tumors (uveal melanoma + cutaneous melanoma + mesothelioma + clear-cell RCC ± atypical Spitz tumors). Prevention-persona RedFlag (§20 v0.2-B).
Clinical direction	investigate
Category	other

Trigger Logic

{
  "any_of": [
    {
      "finding": "family_bap1_known_pathogenic_variant",
      "value": true
    },
    {
      "finding": "family_uveal_melanoma_first_or_second_degree",
      "value": true
    },
    {
      "finding": "family_bap1_spectrum_cluster",
      "value": "true (мезотеліома + меланома + RCC у родині)"
    }
  ],
  "type": "lab_value"
}

Notes

Prevention-persona RedFlag for BAP1 syndrome family history. STUB pending two-Co-Lead signoff.

Used By

Indications

IND-BAP1-SUSPICION-PREVENTION-ENHANCED-SURVEILLANCE - IND-BAP1-SUSPICION-PREVENTION-ENHANCED-SURVEILLANCE
IND-BAP1-SUSPICION-PREVENTION-GENETIC-COUNSELING - IND-BAP1-SUSPICION-PREVENTION-GENETIC-COUNSELING

Red flag

RF-BAP1-CONFIRMED-CARRIER - Confirmed germline pathogenic / likely-pathogenic variant in the BAP1 gene — BAP1 tumor p...