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APL patient elderly (age ≥70) or frail (ECOG ≥2 with comorbidities) — chemo-free ATRA + A...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "comparator": ">=",
      "finding": "age_years",
      "threshold": 70
    },
    {
      "finding": "apl_frail_unfit",
      "value": true
    },
    {
      "all_of": [
        {
          "comparator": ">=",
          "finding": "ecog_performance_status",
          "threshold": 2
        },
        {
          "comparator": ">=",
          "finding": "comorbidities_count",
          "threshold": 2
        }
      ]
    }
  ],
  "type": "composite"
}

Notes

Triggers preference for ATRA + ATO over AIDA-style regimens even in high-risk APL when patient cannot tolerate idarubicin. Outcomes in elderly APL still favorable with ATO-based regimens. STUB — requires clinical co-lead signoff.

Used By

Algorithms

• ALGO-APL-1L - ALGO-APL-1L
• ALGO-APL-2L - ALGO-APL-2L

Indications

• IND-APL-1L-ATRA-ATO-IDA - IND-APL-1L-ATRA-ATO-IDA