AITL with baseline hypogammaglobulinemia (IgG <600 mg/dL) and/or recurrent bacterial infe...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-AITL-HYPOGAMMA`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-AITL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	AITL with baseline hypogammaglobulinemia (IgG <600 mg/dL) and/or recurrent bacterial infections — qualifies for IgG replacement (IVIG) during and after T-cell-directed therapy
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "comparator": "<",
      "finding": "TEST-IMMUNOGLOBULINS",
      "threshold": 600,
      "units": "mg/dL IgG"
    },
    {
      "finding": "hypogamma_present",
      "value": true
    },
    {
      "finding": "recurrent_bacterial_infections",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

AITL produces hypogammaglobulinemia in ~30-50% — paraneoplastic + treatment-related. IgG <400 mg/dL with infection history → IVIG replacement (typically 0.4 g/kg q3-4 weeks targeting trough >500). Continue surveillance post-treatment — recovery often partial. Distinct from rituximab-induced hypogamma (would be late/acquired).

Used By

Algorithms

ALGO-AITL-1L - ALGO-AITL-1L