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AITL with autoimmune hemolytic anemia (AIHA, DAT+) and/or immune thrombocytopenia (ITP) —...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

Red Flag Origin

Trigger Logic

{
  "any_of": [
    {
      "finding": "TEST-DAT-COOMBS",
      "value": "positive"
    },
    {
      "finding": "aiha_present",
      "value": true
    },
    {
      "finding": "itp_present",
      "value": true
    },
    {
      "finding": "hemolysis_features",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

AITL is the T-cell lymphoma most associated with autoimmune cytopenias — AIHA (warm IgG-mediated, DAT+) and ITP can present before, during, or after lymphoma therapy. Standard approach: prednisone-containing chemo (CHOEP/CHP-Bv backbone has prednisone) often controls; refractory cases need rituximab (despite T-cell primary disease — works on B-cell-mediated antibody producers) or IVIG. Monitor reticulocyte + DAT + haptoglobin baseline + during.

Used By

Algorithms

• ALGO-AITL-1L - ALGO-AITL-1L

Indications

• IND-AITL-2L-AZACITIDINE - IND-AITL-2L-AZACITIDINE
• IND-AITL-2L-BELINOSTAT - IND-AITL-2L-BELINOSTAT
• IND-AITL-2L-ROMIDEPSIN - IND-AITL-2L-ROMIDEPSIN
• IND-WM-2L-ZANUBRUTINIB - IND-WM-2L-ZANUBRUTINIB