Bupropion SR
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DRUG-BUPROPION-SR |
|---|---|
| Type | Drug |
| Aliases | Bupropion HCl SRBupropion sustained-releaseWellbutrin SRZybanБупропіон SR |
| Status | reviewed 2026-05-18 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-NCCN-BCELL-2025 |
Drug Facts
| Class | Norepinephrine-dopamine reuptake inhibitor (NDRI); also nicotinic antagonist |
|---|---|
| Mechanism | Weak inhibitor of norepinephrine and dopamine reuptake; non-competitive antagonist at nicotinic acetylcholine receptors. Mechanism in tobacco cessation: dopaminergic effects partially substitute for nicotine's reward signal; nicotinic antagonism reduces reinforcement. Second-line monotherapy for tobacco cessation (USPSTF; lower efficacy than varenicline but similar to NRT). |
| Typical dosing | PO: 150 mg once daily × days 1-3, then 150 mg BID (start ≥1 week before target quit date). Total course 7-12 weeks; extend to 6 months if successful at week 12. Use SR formulation specifically (IR has higher seizure risk; XL is alternative once-daily option). Renal/hepatic impairment: reduce frequency to once daily or every 2 days. |
| Ukraine registered | True |
| NSZU reimbursed | False |
| Ukraine last verified | 2026-05-18 |
Warnings
- Suicidal thoughts and behaviors in pediatric and young adult patients with depression (class warning for antidepressants; bupropion is also an antidepressant)
Notes
STUB — v0.2 prevention-workstream authoring; pending two-Clinical-Co-Lead signoff per CHARTER §6.1 dev-mode. Bupropion SR (Zyban indication) is USPSTF/AHCPR-recommended for tobacco cessation; second-line after varenicline due to lower efficacy and seizure-risk contraindications. Particularly useful when comorbid depression or weight-gain concerns. AVOID in patients also taking tamoxifen (CYP2D6 inhibition reduces active metabolite endoxifen). Source cited (SRC-NCCN-BCELL-2025) is closest in-KB until USPSTF/AHCPR sources land in source-stub workstream.
Used By
No reverse references found in the YAML corpus.