T-Lymphoblastic Leukemia / Lymphoma
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | DIS-T-ALL |
|---|---|
| Type | Disease |
| Aliases | ETP-ALL (subset)T-ALLT-LBLT-Lymphoblastic Leukemia/LymphomaT-лімфобластна лейкемія/лімфома |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | None declared |
| Sources | SRC-NCCN-BCELL-2025 |
Informational support. All recommendations must be verified by a qualified oncologist. Engineering checks are not clinical validation or treatment approval.
| icd_o_3_morphology | 9837/3 |
|---|---|
| icd_10 | C91.0 |
| who_classification | Precursor lymphoid neoplasms — T-lymphoblastic leukaemia/lymphoma per WHO 5th ed. |
Notes
STUB. Hyper-CVAD-based or pediatric-inspired. CD19 CAR-T NOT applicable (T-cell lineage). Rituximab NOT needed (CD20-). Mediastinal mass — possible airway compromise; emergent steroids/cytoreduction before induction.
Used By
Actionability
BMA-IDH2-R140Q-T-ALL- IDH2 mutation in T-ALL is rare. Standard T-ALL protocol; enasidenib off-label R/R conside...BMA-NOTCH1-ACTIVATING-T-ALL- NOTCH1 activating mutations occur in >50% of T-ALL (HD and PEST domains). Gamma-secretase...
Algorithms
ALGO-T-ALL-1L- ALGO-T-ALL-1LALGO-T-ALL-2L- ALGO-T-ALL-2L
Disease
DIS-B-ALL- B-Lymphoblastic Leukemia / Lymphoma
Indication
IND-T-ALL-1L-HYPER-CVAD- IND-T-ALL-1L-HYPER-CVADIND-T-ALL-2L-NELARABINE- IND-T-ALL-2L-NELARABINE
Questionnaires
QUEST-T-ALL-1L-STUB- T-Lymphoblastic Leukemia/Lymphoma — first line
Red flag
RF-RUNX1-CONFIRMED-CARRIER- Confirmed germline pathogenic / likely-pathogenic variant in RUNX1 (Familial Platelet Dis...RF-T-ALL-CNS-LEUKEMIA- T-ALL with CNS-2 (CSF blasts present, WBC <5/µL) or CNS-3 (CSF WBC ≥5/µL with blasts, or...RF-T-ALL-EMERGENCY-TLS-LEUKOSTASIS- T-ALL with hyperleukocytosis (WBC ≥100 K/µL), spontaneous tumor lysis (LDH >2× ULN, uric...RF-T-ALL-FRAILTY-AGE- Age >55 — pediatric-inspired protocols (GRAALL, CALGB 10403) carry excessive induction mo...RF-T-ALL-HIGH-RISK-BIOLOGY- Early T-cell precursor (ETP) phenotype (CD1a-, CD8-, CD5 weak, with myeloid/stem-cell mar...RF-T-ALL-INFECTION-SCREENING- HIV/HBV/HCV/CMV serology + PCP prophylaxis pre-induction; nelarabine-containing regimens...RF-T-ALL-MEDIASTINAL-AIRWAY- T-ALL/T-LBL with anterior mediastinal mass causing airway compromise (stridor, orthopnea,...RF-T-ALL-ORGAN-DYSFUNCTION- Hepatic dysfunction (bilirubin >3xULN OR transaminases >5xULN) — asparaginase + methotrex...RF-T-ALL-TRANSFORMATION-PROGRESSION- MRD-positive post-induction (≥0.01%) OR overt CNS involvement (CNS-3) — alloSCT consolida...