MRD-positive post-induction (≥0.01%) OR overt CNS involvement (CNS-3) — alloSCT consolida...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | RF-T-ALL-TRANSFORMATION-PROGRESSION |
|---|---|
| Type | Red flag |
| Status | reviewed 2026-04-25 | pending_clinical_signoff |
| Diseases | DIS-T-ALL |
| Sources | SRC-ESMO-PTCL-2024 SRC-NCCN-BCELL-2025 |
Red Flag Origin
| Definition | MRD-positive post-induction (≥0.01%) OR overt CNS involvement (CNS-3) — alloSCT consolidation becomes standard; nelarabine-containing salvage if not yet exposed. |
|---|---|
| Clinical direction | investigate |
| Category | transformation-progression |
Trigger Logic
{
"any_of": [
{
"finding": "mrd_positive_post_induction",
"value": true
},
{
"finding": "cns_status_cns3",
"value": true
}
],
"type": "composite_clinical"
}
Notes
MRD-driven consolidation strategy sits downstream of 1L induction Algorithm.
Used By
Algorithms
ALGO-T-ALL-2L- ALGO-T-ALL-2L