HIV/HBV/HCV/CMV serology + PCP prophylaxis pre-induction; nelarabine-containing regimens...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-T-ALL-INFECTION-SCREENING`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-T-ALL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	HIV/HBV/HCV/CMV serology + PCP prophylaxis pre-induction; nelarabine-containing regimens require PJP prophylaxis throughout treatment.
Clinical direction	investigate
Category	infection-screening

Trigger Logic

{
  "any_of": [
    {
      "finding": "hbsag",
      "value": "positive"
    },
    {
      "finding": "hiv_serology",
      "value": "positive"
    },
    {
      "finding": "anti_hcv",
      "value": "positive"
    }
  ],
  "type": "biomarker"
}

Notes

T-ALL induction profoundly lymphopenic; opportunistic infection prophylaxis (PCP, fluconazole, acyclovir) standard regardless of serology — but baseline screen ensures appropriate prophylaxis intensity.

Used By

No reverse references found in the YAML corpus.