Early T-cell precursor (ETP) phenotype (CD1a-, CD8-, CD5 weak, with myeloid/stem-cell mar...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

ID	`RF-T-ALL-HIGH-RISK-BIOLOGY`
Type	Red flag
Status	reviewed 2026-04-25 \| pending_clinical_signoff
Diseases	`DIS-T-ALL`
Sources	`SRC-ESMO-PTCL-2024` `SRC-NCCN-BCELL-2025`

Red Flag Origin

Definition	Early T-cell precursor (ETP) phenotype (CD1a-, CD8-, CD5 weak, with myeloid/stem-cell markers) — historically inferior outcomes with standard T-ALL chemo; nelarabine + alloSCT consolidation considered.
Clinical direction	intensify
Category	high-risk-biology

Trigger Logic

{
  "any_of": [
    {
      "finding": "etp_phenotype",
      "value": true
    },
    {
      "finding": "etp_all",
      "value": true
    }
  ],
  "type": "biomarker"
}

Notes

ETP-ALL is a WHO 2022 distinct entity. Modern MRD-stratified protocols (UKALL14, GRAALL) have closed much of the historical gap, but alloSCT eligibility remains the dominant decision — hence intensify.

Used By

No reverse references found in the YAML corpus.