Onco Wiki / Red flag

Legacy Burkitt high-risk trigger for algorithm review. A fired flag alone does not establ...

Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.

IDRF-BURKITT-HIGH-RISK
TypeRed flag
Statuspending_clinical_signoff
DiseasesDIS-BURKITT
SourcesSRC-ESMO-BURKITT-2024 SRC-NCCN-BCELL-2025

Red Flag Origin

DefinitionLegacy Burkitt high-risk trigger for algorithm review. A fired flag alone does not establish eligibility for the encoded high-risk/no-proven-CNS CODOX/IVAC reference.
Clinical directionintensify
Categoryhigh-risk-biology
Shifts algorithmALGO-BURKITT-1L

Trigger Logic

{
  "any_of": [
    {
      "finding": "burkitt_high_risk",
      "value": true
    },
    {
      "finding": "cns_involvement",
      "value": true
    },
    {
      "finding": "ldh_above_3x_uln",
      "value": true
    },
    {
      "finding": "leukemic_phase",
      "value": true
    },
    {
      "finding": "bulky_abdominal",
      "value": true
    }
  ],
  "type": "composite_clinical"
}

Notes

Trigger logic is retained for legacy trace compatibility, not validated as a complete risk classifier. The indication separately requires explicit high-risk and CNS-negative confirmation; CNS involvement requires a separate protocol. This flag does not mandate CODOX/IVAC or choose an automatic alternative.

Used By

Algorithms

Indication