JAK2 V617F is the defining driver of polycythemia vera (~95%) and a WHO 2022 / ICC 2022 m...
Deterministic view of the source YAML entity. Clinical authority remains with the cited source IDs and reviewer sign-off state.
| ID | BMA-JAK2-V617F-PV |
|---|---|
| Type | Actionability |
| Status | reviewed 2026-04-27 | pending_clinical_signoff | actionability review required |
| Diseases | DIS-PV |
| Sources | SRC-CIVIC SRC-ESMO-MPN-2015 SRC-NCCN-MPN-2025 SRC-PROUD-PV-GISSLINGER-2020 SRC-RESPONSE-VANNUCCHI-2015 |
Actionability Facts
| Biomarker | BIO-JAK2 |
|---|---|
| Variant | V617F (exon 14, JH2 pseudokinase domain — present in ~95% of polycythemia vera) |
| Disease | DIS-PV |
| ESCAT tier | IA |
| Recommended combinations | phlebotomy + low-dose aspirin (low-risk PV per SRC-NCCN-MPN-2025), hydroxyurea (high-risk 1L cytoreduction per SRC-NCCN-MPN-2025, SRC-ESMO-MPN-2015), ropeginterferon alfa-2b (high-risk; preferred for younger patients per SRC-PROUD-PV-GISSLINGER-2020), ruxolitinib (post-hydroxyurea resistance/intolerance per SRC-RESPONSE-VANNUCCHI-2015) |
| Evidence summary | JAK2 V617F is the defining driver of polycythemia vera (~95%) and a WHO 2022 / ICC 2022 major diagnostic criterion (per SRC-NCCN-MPN-2025, SRC-ESMO-MPN-2015). Treatment is risk-stratified, not variant-genotype directed: low-risk PV → phlebotomy + low-dose aspirin; high-risk PV (age ≥60 or prior thrombosis) → cytoreduction with hydroxyurea or interferon-alpha (ropeginterferon-alfa-2b, PROUD-PV / CONTINUATION-PV Gisslinger 2020 — superior molecular response and event-free survival at 5y vs hydroxyurea); ruxolitinib (RESPONSE Vannucchi 2015 — 21% CHR + spleen response vs 1% best available therapy) for hydroxyurea- intolerant or -resistant disease. |
Notes
ESCAT IA / OncoKB Level 1 — JAK2 mutation status is required for diagnosis (WHO 2022 major criterion) and dictates eligibility for JAK-targeted therapy. Risk model: IPSS-PV (age, leukocytosis, thrombosis history). The V617F allele burden may correlate with phenotype severity but is not used as a treatment-selection threshold in current guidelines (per SRC-NCCN-MPN-2025, SRC-ESMO-MPN-2015). Exon 12 JAK2 mutations (~3%) cause idiopathic erythrocytosis with similar management — see notes on detection. Source-gap: SRC-NCCN-MPN-2025 currently STUB; awaits full ingestion.
Used By
No reverse references found in the YAML corpus.